Application of a liquid chromatographic/tandem mass spectrometric method to a urinary excretion study of rabeprazole and two of its metabolites in healthy human urine

•We develop a LC–MS/MS method for quantification of rabeprazole and its metabolites.•The fully validated assay is applied to urine excretion study of rabeprazole in healthy volunteers.•Rabeprazole stock solutions are stable if dissolved in methanol containing 0.5‰ DEA.•Rabeprazole and its two metabo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-04, Vol.988, p.75-80
Hauptverfasser:	Lu, Chengtao, Jia, Yanyan, Song, Ying, Li, Xueqing, Sun, Yuan, Zhao, Jinyi, Wang, Shan, Shi, Lei, Wen, Aidong, Ding, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - metabolism 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacokinetics 2-Pyridinylmethylsulfinylbenzimidazoles - urine Chromatography, Liquid - methods Desmethyl rabeprazole thioether Drug Stability Female Humans LC–MS/MS Linear Models Male Pharmacokinetics Rabeprazole Rabeprazole - metabolism Rabeprazole - pharmacokinetics Rabeprazole - urine Rabeprazole thioether Reproducibility of Results Sensitivity and Specificity Sulfides - metabolism Sulfides - pharmacokinetics Sulfides - urine Tandem Mass Spectrometry - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!