Quinone methide mediates in vitro induction of ornithine decarboxylase by the tumor promoter butylated hydroxytoluene hydroperoxide

Metabolism of the skin tumor promoter butylated hydroxy-toluene hydroperoxide (2,6-di-tert-butyl-4-hydroperoxyl-4-methyl-2,5-cyclohexadienone; BHTOOH) to reactive intermediates is required for tumor promotion by this compound. In particular, an electrophilic quinone methide is known to mediate both...

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Veröffentlicht in:	Carcinogenesis (New York) 1994-05, Vol.15 (5), p.817-821
Hauptverfasser:	Guyton, Kathryn Z., Dolan, Patrick M., Kensler, Thomas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Butylated Hydroxytoluene - analogs & derivatives Butylated Hydroxytoluene - pharmacology Carcinogens - pharmacology Cells, Cultured Chelating Agents - pharmacology Drug Synergism Enzyme Induction Experimental skin tumors Female Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Indolequinones Indoles - pharmacology Isoquinolines - pharmacology Keratinocytes - drug effects Keratinocytes - enzymology Keratinocytes - physiology Medical sciences Mice Molecular Sequence Data Ornithine Decarboxylase - biosynthesis Ornithine Decarboxylase - genetics Ornithine Decarboxylase Inhibitors Papilloma - chemically induced Papilloma - enzymology Peroxides - pharmacology Piperazines - pharmacology Protein Kinase C - antagonists & inhibitors Quinones - pharmacology Skin Neoplasms - chemically induced Skin Neoplasms - enzymology Structure-Activity Relationship Sulfhydryl Compounds - pharmacology Tumors
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