Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles
The main goal of this study was to evaluate the effects of incorporation of calcium phosphate (CaP) particles on the physicochemical properties and mineralization capacity of cements in vitro. Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibit...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2015-04, Vol.103 (3), p.548-555 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Sa, Yue Yang, Fang Leeuwenburgh, Sander C G Wolke, Joop G C Ye, Guang de Wijn, Joost R Jansen, John A Wang, Yining |
| description | The main goal of this study was to evaluate the effects of incorporation of calcium phosphate (CaP) particles on the physicochemical properties and mineralization capacity of cements in vitro. Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibiting an interconnected porosity created by mixing with carboxymethylcellulose. The incorporation of CaP particles did not influence the maximum polymerization temperature of the porous PMMA, but reduced the porosity and the average pore size. Small CaP particles formed agglomerations within the PMMA pores, whereas big CaP particles were partially embedded in the PMMA matrix and partially exposed to the pores. Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction. |
| doi_str_mv | 10.1002/jbm.b.33233 |
| format | Article |
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Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibiting an interconnected porosity created by mixing with carboxymethylcellulose. The incorporation of CaP particles did not influence the maximum polymerization temperature of the porous PMMA, but reduced the porosity and the average pore size. Small CaP particles formed agglomerations within the PMMA pores, whereas big CaP particles were partially embedded in the PMMA matrix and partially exposed to the pores. Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.33233</identifier><identifier>PMID: 24953849</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biocompatible Materials - chemistry ; Biomedical materials ; Bone Cements - chemistry ; Calcium Phosphates - chemistry ; Carboxymethylcellulose Sodium - chemistry ; Compressive Strength ; Crystallization ; Elastic Modulus ; Humans ; Materials research ; Materials science ; Materials Testing ; Microscopy, Electron, Scanning ; Particle Size ; Plasma ; Polymerization ; Polymethyl Methacrylate - chemistry ; Porosity ; Solutions ; Temperature ; X-Ray Diffraction</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2015-04, Vol.103 (3), p.548-555</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-73f7987b7f3dc0dba68b9ffef0255ecadd20cf1e27754f357b1ca2729b21d8f23</citedby><cites>FETCH-LOGICAL-c387t-73f7987b7f3dc0dba68b9ffef0255ecadd20cf1e27754f357b1ca2729b21d8f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24953849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sa, Yue</creatorcontrib><creatorcontrib>Yang, Fang</creatorcontrib><creatorcontrib>Leeuwenburgh, Sander C G</creatorcontrib><creatorcontrib>Wolke, Joop G C</creatorcontrib><creatorcontrib>Ye, Guang</creatorcontrib><creatorcontrib>de Wijn, Joost R</creatorcontrib><creatorcontrib>Jansen, John A</creatorcontrib><creatorcontrib>Wang, Yining</creatorcontrib><title>Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>The main goal of this study was to evaluate the effects of incorporation of calcium phosphate (CaP) particles on the physicochemical properties and mineralization capacity of cements in vitro. Herein, two different types of CaP particles were loaded into polymethylmethacrylate (PMMA) cements exhibiting an interconnected porosity created by mixing with carboxymethylcellulose. The incorporation of CaP particles did not influence the maximum polymerization temperature of the porous PMMA, but reduced the porosity and the average pore size. Small CaP particles formed agglomerations within the PMMA pores, whereas big CaP particles were partially embedded in the PMMA matrix and partially exposed to the pores. Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction.</description><subject>Biocompatible Materials - chemistry</subject><subject>Biomedical materials</subject><subject>Bone Cements - chemistry</subject><subject>Calcium Phosphates - chemistry</subject><subject>Carboxymethylcellulose Sodium - chemistry</subject><subject>Compressive Strength</subject><subject>Crystallization</subject><subject>Elastic Modulus</subject><subject>Humans</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Particle Size</subject><subject>Plasma</subject><subject>Polymerization</subject><subject>Polymethyl Methacrylate - chemistry</subject><subject>Porosity</subject><subject>Solutions</subject><subject>Temperature</subject><subject>X-Ray Diffraction</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1rFTEUBuAgFlurK_cScFOQe50kN5OZpRSrhYIudD3k44TJJZmMSUaZ_gB_dzP2Y9FNThYPb3J4EXpHmj1pGvrpqMJe7RmjjL1AZ4Rzujv0HXn5dBfsFL3O-Vhx23D2Cp3SQ89Zd-jP0L8f45qdjnqE4LT0eE5xhlQcZCwng92E_7iSIg5ugiS9u5XFxQlHi-eY4pLr8GuAMq5-O6VOq5cFsIYAU8E-SgMG_3VlxDVeuyXgeYx5Hjc0y_qS9pDfoBMrfYa3D_Mc_br68vPy2-7m-9fry883O806UXaCWdF3QgnLjG6Mkm2nemvBNpRz0NIY2mhLgArBD5ZxoYiWVNBeUWI6S9k5urjPrWv-XiCXIbiswXs5QV1mIG0rGCeEb_TDM3qMS5rq7zbV0p6KdlMf75VOMecEdpiTCzKtA2mGrZ6h1jOo4X89Vb9_yFxUAPNkH_tgd4yMj6s</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Sa, Yue</creator><creator>Yang, Fang</creator><creator>Leeuwenburgh, Sander C G</creator><creator>Wolke, Joop G C</creator><creator>Ye, Guang</creator><creator>de Wijn, Joost R</creator><creator>Jansen, John A</creator><creator>Wang, Yining</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles</title><author>Sa, Yue ; Yang, Fang ; Leeuwenburgh, Sander C G ; Wolke, Joop G C ; Ye, Guang ; de Wijn, Joost R ; Jansen, John A ; Wang, Yining</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-73f7987b7f3dc0dba68b9ffef0255ecadd20cf1e27754f357b1ca2729b21d8f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biocompatible Materials - chemistry</topic><topic>Biomedical materials</topic><topic>Bone Cements - chemistry</topic><topic>Calcium Phosphates - chemistry</topic><topic>Carboxymethylcellulose Sodium - chemistry</topic><topic>Compressive Strength</topic><topic>Crystallization</topic><topic>Elastic Modulus</topic><topic>Humans</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Particle Size</topic><topic>Plasma</topic><topic>Polymerization</topic><topic>Polymethyl Methacrylate - chemistry</topic><topic>Porosity</topic><topic>Solutions</topic><topic>Temperature</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sa, Yue</creatorcontrib><creatorcontrib>Yang, Fang</creatorcontrib><creatorcontrib>Leeuwenburgh, Sander C G</creatorcontrib><creatorcontrib>Wolke, Joop G C</creatorcontrib><creatorcontrib>Ye, Guang</creatorcontrib><creatorcontrib>de Wijn, Joost R</creatorcontrib><creatorcontrib>Jansen, John A</creatorcontrib><creatorcontrib>Wang, Yining</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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Both types of CaP particles enhanced the mineralization capacity of PMMA cement without compromising their mechanical properties. The data presented herein suggest that porous PMMA/CaP cements hold strong promise for surgical application in bone reconstruction.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24953849</pmid><doi>10.1002/jbm.b.33233</doi><tpages>8</tpages></addata></record> |
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| subjects | Biocompatible Materials - chemistry Biomedical materials Bone Cements - chemistry Calcium Phosphates - chemistry Carboxymethylcellulose Sodium - chemistry Compressive Strength Crystallization Elastic Modulus Humans Materials research Materials science Materials Testing Microscopy, Electron, Scanning Particle Size Plasma Polymerization Polymethyl Methacrylate - chemistry Porosity Solutions Temperature X-Ray Diffraction |
| title | Physicochemical properties and in vitro mineralization of porous polymethylmethacrylate cement loaded with calcium phosphate particles |
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