Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability
Background The concept of borderline resectability has not yet been introduced for extrahepatic cholangiocarcinoma (ECC). In this study, the surgical results of ECC patients were analyzed to clarify the implications of surgery for distal ECC with portal vein (PV) invasion as a preliminary step for t...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2015-04, Vol.22 (4), p.294-300 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
| container_volume | 22 |
| creator | Miura, Fumihiko Sano, Keiji Amano, Hodaka Toyota, Naoyuki Wada, Keita Yoshida, Masahiro Hayano, Koichi Matsubara, Hisahiro Takada, Tadahiro |
| description | Background
The concept of borderline resectability has not yet been introduced for extrahepatic cholangiocarcinoma (ECC). In this study, the surgical results of ECC patients were analyzed to clarify the implications of surgery for distal ECC with portal vein (PV) invasion as a preliminary step for the introduction of the concept of borderline resectability.
Methods
The clinicopathological data of 129 patients who had undergone pancreatoduodenectomy of distal ECC were reviewed retrospectively. Combined PV resection was performed in 10 patients. The clinicopathological variables were evaluated using univariate and multivariate analyses.
Results
Pathological PV invasion was observed in eight of the 129 patients. The survival rates of patients with PV invasion were significantly poorer than those of patients without PV invasion: 3 and 5 years after surgery, 17% and 0% versus 50% and 39% (P < 0.001), respectively. Presence of pancreatic or PV invasion, tumor progression, nodal status, and residual tumor were significant prognostic factors on univariate analysis. On multivariate analysis, PV invasion was the only significant independent predictive factor of a poor prognosis.
Conclusions
PV invasion of distal ECC should be regarded as indicating borderline resectability. |
| doi_str_mv | 10.1002/jhbp.198 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1667351052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3996465441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4778-51cfb1bd376af87e382fec1e22960d2e506bd20abb9303c9d066cedafb8bbb6c3</originalsourceid><addsrcrecordid>eNp1kF1PFDEUhhuiAQIk_AIziTfeDPZj-jGXCrgrAdQI4cKLpu2cka6z07WdWdl_bze7LokJ56YnJ0_evH0QOiX4jGBM388e7eKM1GoPHRIlVClqRV_tdlkdoJOUZjgPI6xmeB8dUM4rQSp1iH5cLk03msGHvghtsQhxMF2xBN8Xvl-atL03Pq3v7jF0pv_pgzPR-T7MTWFSYUNsIHa-hyJCAjcY6zs_rI7R69Z0CU627xG6_3R5dz4tr79MPp9_uC5dJaUqOXGtJbZhUphWSWCKtuAIUFoL3FDgWNiGYmNtLs9c3WAhHDSmtcpaKxw7Qu82uYsYfo-QBj33yUGXq0IYkyZCSMYJ5jSjb_9DZ2GMfW6niZSck4pT_hzoYkgpQqsX0c9NXGmC9dq5XjvX2XlG32wDRzuHZgf-M5yBcgP88R2sXgzSV9OPXzeBWz4bh6cdb-IvnX8huX64nejvF9_4DZ_c6Cn7C2FFm5s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1775514525</pqid></control><display><type>article</type><title>Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Miura, Fumihiko ; Sano, Keiji ; Amano, Hodaka ; Toyota, Naoyuki ; Wada, Keita ; Yoshida, Masahiro ; Hayano, Koichi ; Matsubara, Hisahiro ; Takada, Tadahiro</creator><creatorcontrib>Miura, Fumihiko ; Sano, Keiji ; Amano, Hodaka ; Toyota, Naoyuki ; Wada, Keita ; Yoshida, Masahiro ; Hayano, Koichi ; Matsubara, Hisahiro ; Takada, Tadahiro</creatorcontrib><description>Background
The concept of borderline resectability has not yet been introduced for extrahepatic cholangiocarcinoma (ECC). In this study, the surgical results of ECC patients were analyzed to clarify the implications of surgery for distal ECC with portal vein (PV) invasion as a preliminary step for the introduction of the concept of borderline resectability.
Methods
The clinicopathological data of 129 patients who had undergone pancreatoduodenectomy of distal ECC were reviewed retrospectively. Combined PV resection was performed in 10 patients. The clinicopathological variables were evaluated using univariate and multivariate analyses.
Results
Pathological PV invasion was observed in eight of the 129 patients. The survival rates of patients with PV invasion were significantly poorer than those of patients without PV invasion: 3 and 5 years after surgery, 17% and 0% versus 50% and 39% (P < 0.001), respectively. Presence of pancreatic or PV invasion, tumor progression, nodal status, and residual tumor were significant prognostic factors on univariate analysis. On multivariate analysis, PV invasion was the only significant independent predictive factor of a poor prognosis.
Conclusions
PV invasion of distal ECC should be regarded as indicating borderline resectability.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.198</identifier><identifier>PMID: 25546148</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Aged ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Bile Ducts, Intrahepatic ; Borderline respectability ; Cholangiocarcinoma - mortality ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Distal cholangiocarcinoma ; Female ; Hepatectomy - methods ; Humans ; Japan - epidemiology ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Neoplasm Invasiveness ; Pancreaticoduodenectomy - methods ; Portal Vein ; Portal vein invasion ; Prognosis ; Prognostic factor ; Retrospective Studies ; Survival Rate - trends ; Treatment Outcome</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2015-04, Vol.22 (4), p.294-300</ispartof><rights>2014 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery.</rights><rights>2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4778-51cfb1bd376af87e382fec1e22960d2e506bd20abb9303c9d066cedafb8bbb6c3</citedby><cites>FETCH-LOGICAL-c4778-51cfb1bd376af87e382fec1e22960d2e506bd20abb9303c9d066cedafb8bbb6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.198$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.198$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25546148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miura, Fumihiko</creatorcontrib><creatorcontrib>Sano, Keiji</creatorcontrib><creatorcontrib>Amano, Hodaka</creatorcontrib><creatorcontrib>Toyota, Naoyuki</creatorcontrib><creatorcontrib>Wada, Keita</creatorcontrib><creatorcontrib>Yoshida, Masahiro</creatorcontrib><creatorcontrib>Hayano, Koichi</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Takada, Tadahiro</creatorcontrib><title>Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background
The concept of borderline resectability has not yet been introduced for extrahepatic cholangiocarcinoma (ECC). In this study, the surgical results of ECC patients were analyzed to clarify the implications of surgery for distal ECC with portal vein (PV) invasion as a preliminary step for the introduction of the concept of borderline resectability.
Methods
The clinicopathological data of 129 patients who had undergone pancreatoduodenectomy of distal ECC were reviewed retrospectively. Combined PV resection was performed in 10 patients. The clinicopathological variables were evaluated using univariate and multivariate analyses.
Results
Pathological PV invasion was observed in eight of the 129 patients. The survival rates of patients with PV invasion were significantly poorer than those of patients without PV invasion: 3 and 5 years after surgery, 17% and 0% versus 50% and 39% (P < 0.001), respectively. Presence of pancreatic or PV invasion, tumor progression, nodal status, and residual tumor were significant prognostic factors on univariate analysis. On multivariate analysis, PV invasion was the only significant independent predictive factor of a poor prognosis.
Conclusions
PV invasion of distal ECC should be regarded as indicating borderline resectability.</description><subject>Aged</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Bile Ducts, Intrahepatic</subject><subject>Borderline respectability</subject><subject>Cholangiocarcinoma - mortality</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Distal cholangiocarcinoma</subject><subject>Female</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Neoplasm Invasiveness</subject><subject>Pancreaticoduodenectomy - methods</subject><subject>Portal Vein</subject><subject>Portal vein invasion</subject><subject>Prognosis</subject><subject>Prognostic factor</subject><subject>Retrospective Studies</subject><subject>Survival Rate - trends</subject><subject>Treatment Outcome</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1PFDEUhhuiAQIk_AIziTfeDPZj-jGXCrgrAdQI4cKLpu2cka6z07WdWdl_bze7LokJ56YnJ0_evH0QOiX4jGBM388e7eKM1GoPHRIlVClqRV_tdlkdoJOUZjgPI6xmeB8dUM4rQSp1iH5cLk03msGHvghtsQhxMF2xBN8Xvl-atL03Pq3v7jF0pv_pgzPR-T7MTWFSYUNsIHa-hyJCAjcY6zs_rI7R69Z0CU627xG6_3R5dz4tr79MPp9_uC5dJaUqOXGtJbZhUphWSWCKtuAIUFoL3FDgWNiGYmNtLs9c3WAhHDSmtcpaKxw7Qu82uYsYfo-QBj33yUGXq0IYkyZCSMYJ5jSjb_9DZ2GMfW6niZSck4pT_hzoYkgpQqsX0c9NXGmC9dq5XjvX2XlG32wDRzuHZgf-M5yBcgP88R2sXgzSV9OPXzeBWz4bh6cdb-IvnX8huX64nejvF9_4DZ_c6Cn7C2FFm5s</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Miura, Fumihiko</creator><creator>Sano, Keiji</creator><creator>Amano, Hodaka</creator><creator>Toyota, Naoyuki</creator><creator>Wada, Keita</creator><creator>Yoshida, Masahiro</creator><creator>Hayano, Koichi</creator><creator>Matsubara, Hisahiro</creator><creator>Takada, Tadahiro</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability</title><author>Miura, Fumihiko ; Sano, Keiji ; Amano, Hodaka ; Toyota, Naoyuki ; Wada, Keita ; Yoshida, Masahiro ; Hayano, Koichi ; Matsubara, Hisahiro ; Takada, Tadahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4778-51cfb1bd376af87e382fec1e22960d2e506bd20abb9303c9d066cedafb8bbb6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Bile Ducts, Intrahepatic</topic><topic>Borderline respectability</topic><topic>Cholangiocarcinoma - mortality</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Distal cholangiocarcinoma</topic><topic>Female</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Neoplasm Invasiveness</topic><topic>Pancreaticoduodenectomy - methods</topic><topic>Portal Vein</topic><topic>Portal vein invasion</topic><topic>Prognosis</topic><topic>Prognostic factor</topic><topic>Retrospective Studies</topic><topic>Survival Rate - trends</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miura, Fumihiko</creatorcontrib><creatorcontrib>Sano, Keiji</creatorcontrib><creatorcontrib>Amano, Hodaka</creatorcontrib><creatorcontrib>Toyota, Naoyuki</creatorcontrib><creatorcontrib>Wada, Keita</creatorcontrib><creatorcontrib>Yoshida, Masahiro</creatorcontrib><creatorcontrib>Hayano, Koichi</creatorcontrib><creatorcontrib>Matsubara, Hisahiro</creatorcontrib><creatorcontrib>Takada, Tadahiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miura, Fumihiko</au><au>Sano, Keiji</au><au>Amano, Hodaka</au><au>Toyota, Naoyuki</au><au>Wada, Keita</au><au>Yoshida, Masahiro</au><au>Hayano, Koichi</au><au>Matsubara, Hisahiro</au><au>Takada, Tadahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2015-04</date><risdate>2015</risdate><volume>22</volume><issue>4</issue><spage>294</spage><epage>300</epage><pages>294-300</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background
The concept of borderline resectability has not yet been introduced for extrahepatic cholangiocarcinoma (ECC). In this study, the surgical results of ECC patients were analyzed to clarify the implications of surgery for distal ECC with portal vein (PV) invasion as a preliminary step for the introduction of the concept of borderline resectability.
Methods
The clinicopathological data of 129 patients who had undergone pancreatoduodenectomy of distal ECC were reviewed retrospectively. Combined PV resection was performed in 10 patients. The clinicopathological variables were evaluated using univariate and multivariate analyses.
Results
Pathological PV invasion was observed in eight of the 129 patients. The survival rates of patients with PV invasion were significantly poorer than those of patients without PV invasion: 3 and 5 years after surgery, 17% and 0% versus 50% and 39% (P < 0.001), respectively. Presence of pancreatic or PV invasion, tumor progression, nodal status, and residual tumor were significant prognostic factors on univariate analysis. On multivariate analysis, PV invasion was the only significant independent predictive factor of a poor prognosis.
Conclusions
PV invasion of distal ECC should be regarded as indicating borderline resectability.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>25546148</pmid><doi>10.1002/jhbp.198</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic Borderline respectability Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Distal cholangiocarcinoma Female Hepatectomy - methods Humans Japan - epidemiology Kaplan-Meier Estimate Male Medical prognosis Neoplasm Invasiveness Pancreaticoduodenectomy - methods Portal Vein Portal vein invasion Prognosis Prognostic factor Retrospective Studies Survival Rate - trends Treatment Outcome |
| title | Evaluation of portal vein invasion of distal cholangiocarcinoma as borderline resectability |
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