Comprehensive nutritional status in sarco-osteoporotic older fallers
OBJECTIVES: In older persons, the combination of osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of falls and fractures. However, the particular nutritional status of the sarco-osteoporotic (SOP) patients remains unknown. The goal of this study was to...
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| creator | Huo, Y. R Suriyaarachchi, P Gomez, F Curcio, C. L Boersma, D Gunawardene, P Demontiero, O Duque, Gustavo |
| description | OBJECTIVES: In older persons, the combination of osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of falls and fractures. However, the particular nutritional status of the sarco-osteoporotic (SOP) patients remains unknown. The goal of this study was to obtain a comprehensive picture of nutritional status in SOP patients. DESIGN: Cross-sectional study. SETTING: Falls & Fractures Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 680 subjects (mean age=79, 65% female) assessed between 2008–2013. MEASUREMENTS: Assessment included medical history, mini-nutritional assessment, physical examination, bone densitometry and body composition by DXA, and blood tests for nutritional status (albumin, creatinine, hemoglobin, vitamin D, vitamin B-12, calcium, phosphate and folate). Patients were divided in 4 groups: 1) osteopenia/osteoporosis (BMD |
| doi_str_mv | 10.1007/s12603-014-0543-z |
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R ; Suriyaarachchi, P ; Gomez, F ; Curcio, C. L ; Boersma, D ; Gunawardene, P ; Demontiero, O ; Duque, Gustavo</creator><creatorcontrib>Huo, Y. R ; Suriyaarachchi, P ; Gomez, F ; Curcio, C. L ; Boersma, D ; Gunawardene, P ; Demontiero, O ; Duque, Gustavo</creatorcontrib><description><![CDATA[OBJECTIVES: In older persons, the combination of osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of falls and fractures. However, the particular nutritional status of the sarco-osteoporotic (SOP) patients remains unknown. The goal of this study was to obtain a comprehensive picture of nutritional status in SOP patients. DESIGN: Cross-sectional study. SETTING: Falls & Fractures Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 680 subjects (mean age=79, 65% female) assessed between 2008–2013. MEASUREMENTS: Assessment included medical history, mini-nutritional assessment, physical examination, bone densitometry and body composition by DXA, and blood tests for nutritional status (albumin, creatinine, hemoglobin, vitamin D, vitamin B-12, calcium, phosphate and folate). Patients were divided in 4 groups: 1) osteopenia/osteoporosis (BMD<−1.0 SD); 2) sarcopenia; 3) SOP; and 4) normal (no sarcopenia/no osteoporosis). Difference between groups was assessed with one-way ANOVA and chi square analysis. Multivariable linear regression evaluated the association between the groups and measures of nutritional parameters. RESULTS: Sarcopenia was present in 47.4% of those with osteopenia (167/352) and 62.7% in those with osteoporosis (91/145). Mean age of the SOP was 80.4±7 years. SOP patients showed significantly higher prevalence of falls and fractures. Univariate analyses showed that SOP were more likely than normal to have a BMI< 25 (OR 2.42 95%CI 1.45–4.041, p<0.001), a MNA score <12 (OR 2.0, 95%CI 1.15–3.49, p<0.05), serum folate <20 nmol/L (OR 4.0 95%CI 1.35–11.87, p<0.01) and hemoglobin <120g/L (OR 2.0 95%CI 1.28–3.30, p<0.01). Multivariate analysis showed that a MNA score <12 was independently associated with SOP compared to normal when adjusted for age and gender. Hemoglobin <120g/L, BMI <25, and GDS >6 remained independently associated with SOP after adjustment for all variables including inflammatory conditions. Hypoalbuminemia (<35 g/L) was associated with just osteopenia/osteoporosis (OR: 2.03, 95%CI 1.08–3.81, p<0.01) and just sarcopenia (OR: 1.77, 95%CI 1.0–3.0, p<0.01) compared to normal. No differences in vitamin D, glomerular filtration rate, albumin, corrected calcium, phosphate, red blood cells folate or vitamin B12 levels were found between the subgroups. CONCLUSIONS: In approaching SOP patients, early prevention protocols directed to optimize their nutritional status would be a key strategy to prevent poor outcomes such as falls and fractures in this high risk population. Therefore, nutritional assessment and early nutritional supplementation should be essential domains in this strategy.]]></description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-014-0543-z</identifier><identifier>PMID: 25809813</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Accidental Falls - prevention & control ; Accidental Falls - statistics & numerical data ; age ; Aged ; Aged, 80 and over ; Aging ; albumins ; at-risk population ; Australia ; blood serum ; body composition ; body mass index ; calcium ; Case-Control Studies ; clinical examination ; Clinics ; creatinine ; Cross-Sectional Studies ; densitometry ; Dietary Supplements ; dual-energy X-ray absorptiometry ; elderly ; erythrocytes ; Female ; females ; folic acid ; Fractures ; Fractures, Bone - complications ; Fractures, Bone - epidemiology ; Fractures, Bone - prevention & control ; Geriatric Assessment ; Geriatrics ; Geriatrics/Gerontology ; Gerontology ; glomerular filtration rate ; hematologic tests ; Hemoglobin ; Hospitals ; Humans ; Kinases ; linear models ; Male ; medical history ; Medicine ; Medicine & Public Health ; multivariate analysis ; Neurosciences ; Nutrients ; Nutrition ; Nutrition Assessment ; Nutritional Status ; Older people ; osteopenia ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - epidemiology ; patients ; phosphates ; Prevalence ; Primary Care Medicine ; Protein synthesis ; Proteins ; Quality of Life Research ; risk ; Sarcopenia ; Sarcopenia - complications ; Sarcopenia - epidemiology ; Vitamin B ; vitamin B12 ; Vitamin D</subject><ispartof>The Journal of nutrition, health & aging, 2015-04, Vol.19 (4), p.474-480</ispartof><rights>Serdi and Springer-Verlag France 2014</rights><rights>Serdi and Springer-Verlag France 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-392a3e697e55ebfcd10fe9dec9f1322a08c85e2c74fd98f03d34ae32282bc6993</citedby><cites>FETCH-LOGICAL-c575t-392a3e697e55ebfcd10fe9dec9f1322a08c85e2c74fd98f03d34ae32282bc6993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-014-0543-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-014-0543-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25809813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, Y. R</creatorcontrib><creatorcontrib>Suriyaarachchi, P</creatorcontrib><creatorcontrib>Gomez, F</creatorcontrib><creatorcontrib>Curcio, C. L</creatorcontrib><creatorcontrib>Boersma, D</creatorcontrib><creatorcontrib>Gunawardene, P</creatorcontrib><creatorcontrib>Demontiero, O</creatorcontrib><creatorcontrib>Duque, Gustavo</creatorcontrib><title>Comprehensive nutritional status in sarco-osteoporotic older fallers</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description><![CDATA[OBJECTIVES: In older persons, the combination of osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of falls and fractures. However, the particular nutritional status of the sarco-osteoporotic (SOP) patients remains unknown. The goal of this study was to obtain a comprehensive picture of nutritional status in SOP patients. DESIGN: Cross-sectional study. SETTING: Falls & Fractures Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 680 subjects (mean age=79, 65% female) assessed between 2008–2013. MEASUREMENTS: Assessment included medical history, mini-nutritional assessment, physical examination, bone densitometry and body composition by DXA, and blood tests for nutritional status (albumin, creatinine, hemoglobin, vitamin D, vitamin B-12, calcium, phosphate and folate). Patients were divided in 4 groups: 1) osteopenia/osteoporosis (BMD<−1.0 SD); 2) sarcopenia; 3) SOP; and 4) normal (no sarcopenia/no osteoporosis). Difference between groups was assessed with one-way ANOVA and chi square analysis. Multivariable linear regression evaluated the association between the groups and measures of nutritional parameters. RESULTS: Sarcopenia was present in 47.4% of those with osteopenia (167/352) and 62.7% in those with osteoporosis (91/145). Mean age of the SOP was 80.4±7 years. SOP patients showed significantly higher prevalence of falls and fractures. Univariate analyses showed that SOP were more likely than normal to have a BMI< 25 (OR 2.42 95%CI 1.45–4.041, p<0.001), a MNA score <12 (OR 2.0, 95%CI 1.15–3.49, p<0.05), serum folate <20 nmol/L (OR 4.0 95%CI 1.35–11.87, p<0.01) and hemoglobin <120g/L (OR 2.0 95%CI 1.28–3.30, p<0.01). Multivariate analysis showed that a MNA score <12 was independently associated with SOP compared to normal when adjusted for age and gender. Hemoglobin <120g/L, BMI <25, and GDS >6 remained independently associated with SOP after adjustment for all variables including inflammatory conditions. Hypoalbuminemia (<35 g/L) was associated with just osteopenia/osteoporosis (OR: 2.03, 95%CI 1.08–3.81, p<0.01) and just sarcopenia (OR: 1.77, 95%CI 1.0–3.0, p<0.01) compared to normal. No differences in vitamin D, glomerular filtration rate, albumin, corrected calcium, phosphate, red blood cells folate or vitamin B12 levels were found between the subgroups. CONCLUSIONS: In approaching SOP patients, early prevention protocols directed to optimize their nutritional status would be a key strategy to prevent poor outcomes such as falls and fractures in this high risk population. Therefore, nutritional assessment and early nutritional supplementation should be essential domains in this strategy.]]></description><subject>Accidental Falls - prevention & control</subject><subject>Accidental Falls - statistics & numerical data</subject><subject>age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>albumins</subject><subject>at-risk population</subject><subject>Australia</subject><subject>blood serum</subject><subject>body composition</subject><subject>body mass index</subject><subject>calcium</subject><subject>Case-Control Studies</subject><subject>clinical examination</subject><subject>Clinics</subject><subject>creatinine</subject><subject>Cross-Sectional Studies</subject><subject>densitometry</subject><subject>Dietary Supplements</subject><subject>dual-energy X-ray absorptiometry</subject><subject>elderly</subject><subject>erythrocytes</subject><subject>Female</subject><subject>females</subject><subject>folic acid</subject><subject>Fractures</subject><subject>Fractures, Bone - complications</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fractures, Bone - prevention & control</subject><subject>Geriatric Assessment</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Gerontology</subject><subject>glomerular filtration rate</subject><subject>hematologic tests</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kinases</subject><subject>linear models</subject><subject>Male</subject><subject>medical history</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multivariate analysis</subject><subject>Neurosciences</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Older people</subject><subject>osteopenia</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - epidemiology</subject><subject>patients</subject><subject>phosphates</subject><subject>Prevalence</subject><subject>Primary Care Medicine</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Quality of Life Research</subject><subject>risk</subject><subject>Sarcopenia</subject><subject>Sarcopenia - complications</subject><subject>Sarcopenia - epidemiology</subject><subject>Vitamin B</subject><subject>vitamin B12</subject><subject>Vitamin D</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kM2u0zAQhS0E4pbCA7CBSGzYGMZ24p8l6uVPqsQCurZcZ1JylcbFk1yJPj2uUhBiwcojzXeONR9jzwW8EQDmLQmpQXEQNYemVvz8gK2E0cBrY-3DMkvjuDFgbtgTojuAunFWP2Y3srHgrFArdrtJx1PG7zhSf4_VOE-5n_o0hqGiKUwzVf1YUcgx8UQTplPKaepjlYYWc9WFYcBMT9mjMhE-u75rtvvw_tvmE99--fh5827LY2OaiSsng0LtDDYN7rvYCujQtRhdJ5SUAWy0Dcpo6q51tgPVqjpg2Vi5j9o5tWavl95TTj9mpMkfe4o4DGHENJMXWhtVO6FUQV_9g96lOZezLpSRUgslZKHEQsWciDJ2_pT7Y8g_vQB_UewXxb4o9hfF_lwyL67N8_6I7Z_Eb6cFkAtAZTUeMP_19X9aXy6hLiQfDrknv_sqQWgAsFqBVb8AdyaQkg</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Huo, Y. 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R ; Suriyaarachchi, P ; Gomez, F ; Curcio, C. L ; Boersma, D ; Gunawardene, P ; Demontiero, O ; Duque, Gustavo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-392a3e697e55ebfcd10fe9dec9f1322a08c85e2c74fd98f03d34ae32282bc6993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accidental Falls - prevention & control</topic><topic>Accidental Falls - statistics & numerical data</topic><topic>age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>albumins</topic><topic>at-risk population</topic><topic>Australia</topic><topic>blood serum</topic><topic>body composition</topic><topic>body mass index</topic><topic>calcium</topic><topic>Case-Control Studies</topic><topic>clinical examination</topic><topic>Clinics</topic><topic>creatinine</topic><topic>Cross-Sectional Studies</topic><topic>densitometry</topic><topic>Dietary Supplements</topic><topic>dual-energy X-ray absorptiometry</topic><topic>elderly</topic><topic>erythrocytes</topic><topic>Female</topic><topic>females</topic><topic>folic acid</topic><topic>Fractures</topic><topic>Fractures, Bone - complications</topic><topic>Fractures, Bone - epidemiology</topic><topic>Fractures, Bone - prevention & control</topic><topic>Geriatric Assessment</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Gerontology</topic><topic>glomerular filtration rate</topic><topic>hematologic tests</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Kinases</topic><topic>linear models</topic><topic>Male</topic><topic>medical history</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multivariate analysis</topic><topic>Neurosciences</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Older people</topic><topic>osteopenia</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - epidemiology</topic><topic>patients</topic><topic>phosphates</topic><topic>Prevalence</topic><topic>Primary Care Medicine</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Quality of Life Research</topic><topic>risk</topic><topic>Sarcopenia</topic><topic>Sarcopenia - complications</topic><topic>Sarcopenia - epidemiology</topic><topic>Vitamin B</topic><topic>vitamin B12</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Y. R</creatorcontrib><creatorcontrib>Suriyaarachchi, P</creatorcontrib><creatorcontrib>Gomez, F</creatorcontrib><creatorcontrib>Curcio, C. 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R</au><au>Suriyaarachchi, P</au><au>Gomez, F</au><au>Curcio, C. L</au><au>Boersma, D</au><au>Gunawardene, P</au><au>Demontiero, O</au><au>Duque, Gustavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive nutritional status in sarco-osteoporotic older fallers</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>19</volume><issue>4</issue><spage>474</spage><epage>480</epage><pages>474-480</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract><![CDATA[OBJECTIVES: In older persons, the combination of osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of falls and fractures. However, the particular nutritional status of the sarco-osteoporotic (SOP) patients remains unknown. The goal of this study was to obtain a comprehensive picture of nutritional status in SOP patients. DESIGN: Cross-sectional study. SETTING: Falls & Fractures Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 680 subjects (mean age=79, 65% female) assessed between 2008–2013. MEASUREMENTS: Assessment included medical history, mini-nutritional assessment, physical examination, bone densitometry and body composition by DXA, and blood tests for nutritional status (albumin, creatinine, hemoglobin, vitamin D, vitamin B-12, calcium, phosphate and folate). Patients were divided in 4 groups: 1) osteopenia/osteoporosis (BMD<−1.0 SD); 2) sarcopenia; 3) SOP; and 4) normal (no sarcopenia/no osteoporosis). Difference between groups was assessed with one-way ANOVA and chi square analysis. Multivariable linear regression evaluated the association between the groups and measures of nutritional parameters. RESULTS: Sarcopenia was present in 47.4% of those with osteopenia (167/352) and 62.7% in those with osteoporosis (91/145). Mean age of the SOP was 80.4±7 years. SOP patients showed significantly higher prevalence of falls and fractures. Univariate analyses showed that SOP were more likely than normal to have a BMI< 25 (OR 2.42 95%CI 1.45–4.041, p<0.001), a MNA score <12 (OR 2.0, 95%CI 1.15–3.49, p<0.05), serum folate <20 nmol/L (OR 4.0 95%CI 1.35–11.87, p<0.01) and hemoglobin <120g/L (OR 2.0 95%CI 1.28–3.30, p<0.01). Multivariate analysis showed that a MNA score <12 was independently associated with SOP compared to normal when adjusted for age and gender. Hemoglobin <120g/L, BMI <25, and GDS >6 remained independently associated with SOP after adjustment for all variables including inflammatory conditions. Hypoalbuminemia (<35 g/L) was associated with just osteopenia/osteoporosis (OR: 2.03, 95%CI 1.08–3.81, p<0.01) and just sarcopenia (OR: 1.77, 95%CI 1.0–3.0, p<0.01) compared to normal. No differences in vitamin D, glomerular filtration rate, albumin, corrected calcium, phosphate, red blood cells folate or vitamin B12 levels were found between the subgroups. CONCLUSIONS: In approaching SOP patients, early prevention protocols directed to optimize their nutritional status would be a key strategy to prevent poor outcomes such as falls and fractures in this high risk population. Therefore, nutritional assessment and early nutritional supplementation should be essential domains in this strategy.]]></abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>25809813</pmid><doi>10.1007/s12603-014-0543-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2015-04, Vol.19 (4), p.474-480 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1667349133 |
| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Accidental Falls - prevention & control Accidental Falls - statistics & numerical data age Aged Aged, 80 and over Aging albumins at-risk population Australia blood serum body composition body mass index calcium Case-Control Studies clinical examination Clinics creatinine Cross-Sectional Studies densitometry Dietary Supplements dual-energy X-ray absorptiometry elderly erythrocytes Female females folic acid Fractures Fractures, Bone - complications Fractures, Bone - epidemiology Fractures, Bone - prevention & control Geriatric Assessment Geriatrics Geriatrics/Gerontology Gerontology glomerular filtration rate hematologic tests Hemoglobin Hospitals Humans Kinases linear models Male medical history Medicine Medicine & Public Health multivariate analysis Neurosciences Nutrients Nutrition Nutrition Assessment Nutritional Status Older people osteopenia Osteoporosis Osteoporosis - complications Osteoporosis - epidemiology patients phosphates Prevalence Primary Care Medicine Protein synthesis Proteins Quality of Life Research risk Sarcopenia Sarcopenia - complications Sarcopenia - epidemiology Vitamin B vitamin B12 Vitamin D |
| title | Comprehensive nutritional status in sarco-osteoporotic older fallers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T07%3A16%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comprehensive%20nutritional%20status%20in%20sarco-osteoporotic%20older%20fallers&rft.jtitle=The%20Journal%20of%20nutrition,%20health%20&%20aging&rft.au=Huo,%20Y.%20R&rft.date=2015-04-01&rft.volume=19&rft.issue=4&rft.spage=474&rft.epage=480&rft.pages=474-480&rft.issn=1279-7707&rft.eissn=1760-4788&rft_id=info:doi/10.1007/s12603-014-0543-z&rft_dat=%3Cproquest_cross%3E1667349133%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672261312&rft_id=info:pmid/25809813&rfr_iscdi=true |