MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2

In this study, we attempted to uncover the functional impact of microRNA-22 (miR-22) and its target gene in smooth muscle cell (SMC) differentiation and delineate the molecular mechanism involved. miR-22 was found to be significantly upregulated during SMC differentiation from embryonic stem cells a...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-04, Vol.35 (4), p.918-929
Hauptverfasser:	Zhao, Hanqing, Wen, Guanmei, Wen, Guammei, Huang, Yuan, Yu, Xiaotian, Chen, Qishan, Afzal, Tayyab Adeel, Luong, Le Anh, Zhu, Jianhua, Ye, Shu, Shu, Ye, Zhang, Li, Xiao, Qingzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Becaplermin Binding Sites Cell Differentiation - drug effects Cell Line Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Epigenesis, Genetic Gene Expression Regulation Histones - metabolism Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism Methylation Mice MicroRNAs - genetics MicroRNAs - metabolism Mutation Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oligonucleotides - metabolism Phospholipases A2 - genetics Phospholipases A2 - metabolism Proto-Oncogene Proteins c-sis - pharmacology RNA Interference Serum Response Element Serum Response Factor - genetics Serum Response Factor - metabolism Signal Transduction Time Factors Trans-Activators - genetics Trans-Activators - metabolism Transcription, Genetic Transfection Transforming Growth Factor beta - pharmacology
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