Determination of fexofenadine in Hank's balanced salt solution by high-performance liquid chromatography with ultraviolet detection: application to Caco-2 cell permeability studies

The drug‐transporting proteins can affect the pharmacokinetics and pharmacodymanics of many drugs, resulting in an erratic and unpredictable pharmacological response. The Caco‐2 monolayer is routinely applied to investigate the carrier‐mediated transport of drugs. Therefore, the selection of a marke...

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Veröffentlicht in:	Biomedical chromatography 2015-04, Vol.29 (4), p.537-544
Hauptverfasser:	Júnior, Marco Antônio dos. Reis, de Faria, Ana Cláudia Miranda, Velozo, Eudes da. Silva, Dalla Costa, Teresa, de Andrade, Frank Pereira, de Castro, Whocely Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Caco-2 Cells Cells - chemistry Cells - drug effects Cells - metabolism Chromatography, High Pressure Liquid - methods Culture Media - chemistry Culture Media - metabolism fexofenadine HPLC-UV Humans Membrane Transport Proteins - metabolism Permeability Terfenadine - analogs & derivatives Terfenadine - analysis Terfenadine - metabolism
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