Human papillomavirus infection and immunohistochemical p16(INK4a) expression as predictors of outcome in penile squamous cell carcinomas

Approximately 50% of penile squamous cell carcinomas (SCC) are associated with high-risk human papillomavirus (HR-HPV) infection. We evaluated the correlation of p16(INK4a) expression and HR-HPV with clinicopathological features and outcome in a cohort of patients with penile SCC. Two tissue microar...

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Veröffentlicht in:	Human pathology 2015-04, Vol.46 (4), p.532-540
Hauptverfasser:	Bezerra, Stephania M, Chaux, Alcides, Ball, Mark W, Faraj, Sheila F, Munari, Enrico, Gonzalez-Roibon, Nilda, Sharma, Rajni, Bivalacqua, Trinity J, Burnett, Arthur L, Netto, George J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cyclin-Dependent Kinase Inhibitor p16 - metabolism Humans Immunohistochemistry - methods Male Middle Aged Neoplasm Invasiveness Papillomavirus Infections - complications Papillomavirus Infections - metabolism Papillomavirus Infections - pathology Penile Neoplasms - metabolism Penile Neoplasms - pathology Penile Neoplasms - virology Predictive Value of Tests Prognosis
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