Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells

Elevated expression of the c-myc oncogene is a frequent finding in tumors and cell lines derived from carcinomas of the colon and rectum. In a previous study we demonstrated that the differentiation agent sodium butyrate causes a rapid reduction in the expression of c-myc RNA in the rectal carcinoma...

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Veröffentlicht in:	The Journal of biological chemistry 1993-09, Vol.268 (27), p.20466-20472
Hauptverfasser:	HERUTH, D. P, ZIRNSTEIN, G. W, BRANDLEY, J. F, ROTHBERG, P. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense Elements (Genetics) Biological and medical sciences Blotting, Northern Butyrates - pharmacology Butyric Acid Cell Differentiation - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Dimethyl Sulfoxide - pharmacology DNA Probes Exons Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, myc - drug effects Humans Introns Kinetics Leukemia, Promyelocytic, Acute Molecular and cellular biology Molecular genetics Promoter Regions, Genetic - drug effects Rectal Neoplasms RNA Probes RNA, Neoplasm - genetics RNA, Neoplasm - isolation & purification Transcription, Genetic - drug effects Transcription. Transcription factor. Splicing. Rna processing Tumor Cells, Cultured
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