Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation
Because microvascular disease is one of the most important drivers of diabetic complications, early monitoring of microvascular integrity may be of clinical value. By assessing profiles of circulating microRNAs (miRNAs), known regulators of microvascular pathophysiology, in healthy controls and diab...
Gespeichert in:
| Veröffentlicht in: | American journal of transplantation 2015-04, Vol.15 (4), p.1081-1090 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1090 |
|---|---|
| container_issue | 4 |
| container_start_page | 1081 |
| container_title | American journal of transplantation |
| container_volume | 15 |
| creator | Bijkerk, R. Duijs, J. M. G. J. Khairoun, M. ter Horst, C. J. H. van der Pol, P. Mallat, M. J. Rotmans, J. I. de Vries, A. P. J. de Koning, E. J. de Fijter, J. W. Rabelink, T. J. van Zonneveld, A. J. Reinders, M. E. J. |
| description | Because microvascular disease is one of the most important drivers of diabetic complications, early monitoring of microvascular integrity may be of clinical value. By assessing profiles of circulating microRNAs (miRNAs), known regulators of microvascular pathophysiology, in healthy controls and diabetic nephropathy (DN) patients before and after simultaneous pancreas–kidney transplantation (SPK), we aimed to identify differentially expressed miRNAs that associate with microvascular impairment. Following a pilot study, we selected 13 candidate miRNAs and determined their circulating levels in DN (n = 21), SPK‐patients (n = 37), healthy controls (n = 19), type 1 diabetes mellitus patients (n = 15) and DN patients with a kidney transplant (n = 15). For validation of selected miRNAs, 14 DN patients were studied longitudinally up to 12 months after SPK. We demonstrated a direct association of miR‐25, ‐27a, ‐126, ‐130b, ‐132, ‐152, ‐181a, ‐223, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 with DN. Of those, miR‐25, ‐27a, ‐130b, ‐132, ‐152, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 normalized after SPK. Importantly, circulating levels of some of these miRNAs tightly associate with microvascular impairment as they relate to aberrant capillary tortuosity, angiopoietin‐2/angiopoietin‐1 ratios, circulating levels of soluble‐thrombomodulin and insulin‐like growth factor. Taken together, circulating miRNA profiles associate with DN and systemic microvascular damage, and might serve to identify individuals at risk of experiencing microvascular complications, as well as give insight into underlying pathologies.
Selected circulating microRNAs correlate with diabetic nephropathy and systemic microvascular damage, and normalize after simultaneous pancreas–kidney transplantation, providing novel opportunities for the identification of patients at risk for microvascular complications and pathways involved in disease progression. |
| doi_str_mv | 10.1111/ajt.13072 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1666727573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3629232011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3882-d4a219db3cbc46d98e53818c0423c9fa237ef616fa108d0101ea2507c751d6483</originalsourceid><addsrcrecordid>eNp1kctu1DAUhiMEoqWw4AWQJTawmNaXxPYsoym3UgZEB7GMzjgnHY9yq-2Awqrv0D0P1yfBMyldIOGNLfk7n36dP0meM3rM4jmBbThmgir-IDlkktKZZKl4eP8W2UHyxPstpUxxzR8nBzxTTKacHya_F9aZoYZg20vyyRrXfV3mnuTed8ZCQPLdhg05tbDGYA1ZYr9xXQ9hMxJoS3Ix-oBN_NiP_gC_czlyCg1c4p5Ydq6B2v5CklcBHbmwzVAHaLEbPPkCrXEI_vb65qMtWxzJykHr-xraECN17dPkUQW1x2d391Hy7e2b1eL97Pzzuw-L_HxmhNZ8VqbA2bxcC7M2qSznGjOhmTY05cLMK-BCYSWZrIBRXVJGGQLPqDIqY6VMtThKXk3e3nVXA_pQNNYbrOspaMGklIqrTImIvvwH3XaDa2O6HZVmc61TFanXExXX4r3DquidbcCNBaPFrrQillbsS4vsizvjsG6wvCf_thSBkwn4aWsc_28q8rPVpPwD1qajow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1664598847</pqid></control><display><type>article</type><title>Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Bijkerk, R. ; Duijs, J. M. G. J. ; Khairoun, M. ; ter Horst, C. J. H. ; van der Pol, P. ; Mallat, M. J. ; Rotmans, J. I. ; de Vries, A. P. J. ; de Koning, E. J. ; de Fijter, J. W. ; Rabelink, T. J. ; van Zonneveld, A. J. ; Reinders, M. E. J.</creator><creatorcontrib>Bijkerk, R. ; Duijs, J. M. G. J. ; Khairoun, M. ; ter Horst, C. J. H. ; van der Pol, P. ; Mallat, M. J. ; Rotmans, J. I. ; de Vries, A. P. J. ; de Koning, E. J. ; de Fijter, J. W. ; Rabelink, T. J. ; van Zonneveld, A. J. ; Reinders, M. E. J.</creatorcontrib><description>Because microvascular disease is one of the most important drivers of diabetic complications, early monitoring of microvascular integrity may be of clinical value. By assessing profiles of circulating microRNAs (miRNAs), known regulators of microvascular pathophysiology, in healthy controls and diabetic nephropathy (DN) patients before and after simultaneous pancreas–kidney transplantation (SPK), we aimed to identify differentially expressed miRNAs that associate with microvascular impairment. Following a pilot study, we selected 13 candidate miRNAs and determined their circulating levels in DN (n = 21), SPK‐patients (n = 37), healthy controls (n = 19), type 1 diabetes mellitus patients (n = 15) and DN patients with a kidney transplant (n = 15). For validation of selected miRNAs, 14 DN patients were studied longitudinally up to 12 months after SPK. We demonstrated a direct association of miR‐25, ‐27a, ‐126, ‐130b, ‐132, ‐152, ‐181a, ‐223, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 with DN. Of those, miR‐25, ‐27a, ‐130b, ‐132, ‐152, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 normalized after SPK. Importantly, circulating levels of some of these miRNAs tightly associate with microvascular impairment as they relate to aberrant capillary tortuosity, angiopoietin‐2/angiopoietin‐1 ratios, circulating levels of soluble‐thrombomodulin and insulin‐like growth factor. Taken together, circulating miRNA profiles associate with DN and systemic microvascular damage, and might serve to identify individuals at risk of experiencing microvascular complications, as well as give insight into underlying pathologies.
Selected circulating microRNAs correlate with diabetic nephropathy and systemic microvascular damage, and normalize after simultaneous pancreas–kidney transplantation, providing novel opportunities for the identification of patients at risk for microvascular complications and pathways involved in disease progression.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.13072</identifier><identifier>PMID: 25716422</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adolescent ; Adult ; basic (laboratory) research/science ; biomarker ; clinical research/practice ; Diabetes ; diabetes: secondary complications ; Diabetic Nephropathies - blood ; Female ; Humans ; Kidney Transplantation ; kidney transplantation/nephrology ; Male ; MicroRNAs ; MicroRNAs - blood ; Middle Aged ; molecular biology: micro RNA ; Pancreas ; Pancreas Transplantation ; pancreas/simultaneous pancreas–kidney transplantation ; Transplants & implants ; vascular biology ; Young Adult</subject><ispartof>American journal of transplantation, 2015-04, Vol.15 (4), p.1081-1090</ispartof><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-d4a219db3cbc46d98e53818c0423c9fa237ef616fa108d0101ea2507c751d6483</citedby><cites>FETCH-LOGICAL-c3882-d4a219db3cbc46d98e53818c0423c9fa237ef616fa108d0101ea2507c751d6483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.13072$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.13072$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25716422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bijkerk, R.</creatorcontrib><creatorcontrib>Duijs, J. M. G. J.</creatorcontrib><creatorcontrib>Khairoun, M.</creatorcontrib><creatorcontrib>ter Horst, C. J. H.</creatorcontrib><creatorcontrib>van der Pol, P.</creatorcontrib><creatorcontrib>Mallat, M. J.</creatorcontrib><creatorcontrib>Rotmans, J. I.</creatorcontrib><creatorcontrib>de Vries, A. P. J.</creatorcontrib><creatorcontrib>de Koning, E. J.</creatorcontrib><creatorcontrib>de Fijter, J. W.</creatorcontrib><creatorcontrib>Rabelink, T. J.</creatorcontrib><creatorcontrib>van Zonneveld, A. J.</creatorcontrib><creatorcontrib>Reinders, M. E. J.</creatorcontrib><title>Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Because microvascular disease is one of the most important drivers of diabetic complications, early monitoring of microvascular integrity may be of clinical value. By assessing profiles of circulating microRNAs (miRNAs), known regulators of microvascular pathophysiology, in healthy controls and diabetic nephropathy (DN) patients before and after simultaneous pancreas–kidney transplantation (SPK), we aimed to identify differentially expressed miRNAs that associate with microvascular impairment. Following a pilot study, we selected 13 candidate miRNAs and determined their circulating levels in DN (n = 21), SPK‐patients (n = 37), healthy controls (n = 19), type 1 diabetes mellitus patients (n = 15) and DN patients with a kidney transplant (n = 15). For validation of selected miRNAs, 14 DN patients were studied longitudinally up to 12 months after SPK. We demonstrated a direct association of miR‐25, ‐27a, ‐126, ‐130b, ‐132, ‐152, ‐181a, ‐223, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 with DN. Of those, miR‐25, ‐27a, ‐130b, ‐132, ‐152, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 normalized after SPK. Importantly, circulating levels of some of these miRNAs tightly associate with microvascular impairment as they relate to aberrant capillary tortuosity, angiopoietin‐2/angiopoietin‐1 ratios, circulating levels of soluble‐thrombomodulin and insulin‐like growth factor. Taken together, circulating miRNA profiles associate with DN and systemic microvascular damage, and might serve to identify individuals at risk of experiencing microvascular complications, as well as give insight into underlying pathologies.
Selected circulating microRNAs correlate with diabetic nephropathy and systemic microvascular damage, and normalize after simultaneous pancreas–kidney transplantation, providing novel opportunities for the identification of patients at risk for microvascular complications and pathways involved in disease progression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>basic (laboratory) research/science</subject><subject>biomarker</subject><subject>clinical research/practice</subject><subject>Diabetes</subject><subject>diabetes: secondary complications</subject><subject>Diabetic Nephropathies - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>kidney transplantation/nephrology</subject><subject>Male</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>Middle Aged</subject><subject>molecular biology: micro RNA</subject><subject>Pancreas</subject><subject>Pancreas Transplantation</subject><subject>pancreas/simultaneous pancreas–kidney transplantation</subject><subject>Transplants & implants</subject><subject>vascular biology</subject><subject>Young Adult</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhiMEoqWw4AWQJTawmNaXxPYsoym3UgZEB7GMzjgnHY9yq-2Awqrv0D0P1yfBMyldIOGNLfk7n36dP0meM3rM4jmBbThmgir-IDlkktKZZKl4eP8W2UHyxPstpUxxzR8nBzxTTKacHya_F9aZoYZg20vyyRrXfV3mnuTed8ZCQPLdhg05tbDGYA1ZYr9xXQ9hMxJoS3Ix-oBN_NiP_gC_czlyCg1c4p5Ydq6B2v5CklcBHbmwzVAHaLEbPPkCrXEI_vb65qMtWxzJykHr-xraECN17dPkUQW1x2d391Hy7e2b1eL97Pzzuw-L_HxmhNZ8VqbA2bxcC7M2qSznGjOhmTY05cLMK-BCYSWZrIBRXVJGGQLPqDIqY6VMtThKXk3e3nVXA_pQNNYbrOspaMGklIqrTImIvvwH3XaDa2O6HZVmc61TFanXExXX4r3DquidbcCNBaPFrrQillbsS4vsizvjsG6wvCf_thSBkwn4aWsc_28q8rPVpPwD1qajow</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Bijkerk, R.</creator><creator>Duijs, J. M. G. J.</creator><creator>Khairoun, M.</creator><creator>ter Horst, C. J. H.</creator><creator>van der Pol, P.</creator><creator>Mallat, M. J.</creator><creator>Rotmans, J. I.</creator><creator>de Vries, A. P. J.</creator><creator>de Koning, E. J.</creator><creator>de Fijter, J. W.</creator><creator>Rabelink, T. J.</creator><creator>van Zonneveld, A. J.</creator><creator>Reinders, M. E. J.</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation</title><author>Bijkerk, R. ; Duijs, J. M. G. J. ; Khairoun, M. ; ter Horst, C. J. H. ; van der Pol, P. ; Mallat, M. J. ; Rotmans, J. I. ; de Vries, A. P. J. ; de Koning, E. J. ; de Fijter, J. W. ; Rabelink, T. J. ; van Zonneveld, A. J. ; Reinders, M. E. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-d4a219db3cbc46d98e53818c0423c9fa237ef616fa108d0101ea2507c751d6483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>basic (laboratory) research/science</topic><topic>biomarker</topic><topic>clinical research/practice</topic><topic>Diabetes</topic><topic>diabetes: secondary complications</topic><topic>Diabetic Nephropathies - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>kidney transplantation/nephrology</topic><topic>Male</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>Middle Aged</topic><topic>molecular biology: micro RNA</topic><topic>Pancreas</topic><topic>Pancreas Transplantation</topic><topic>pancreas/simultaneous pancreas–kidney transplantation</topic><topic>Transplants & implants</topic><topic>vascular biology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bijkerk, R.</creatorcontrib><creatorcontrib>Duijs, J. M. G. J.</creatorcontrib><creatorcontrib>Khairoun, M.</creatorcontrib><creatorcontrib>ter Horst, C. J. H.</creatorcontrib><creatorcontrib>van der Pol, P.</creatorcontrib><creatorcontrib>Mallat, M. J.</creatorcontrib><creatorcontrib>Rotmans, J. I.</creatorcontrib><creatorcontrib>de Vries, A. P. J.</creatorcontrib><creatorcontrib>de Koning, E. J.</creatorcontrib><creatorcontrib>de Fijter, J. W.</creatorcontrib><creatorcontrib>Rabelink, T. J.</creatorcontrib><creatorcontrib>van Zonneveld, A. J.</creatorcontrib><creatorcontrib>Reinders, M. E. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bijkerk, R.</au><au>Duijs, J. M. G. J.</au><au>Khairoun, M.</au><au>ter Horst, C. J. H.</au><au>van der Pol, P.</au><au>Mallat, M. J.</au><au>Rotmans, J. I.</au><au>de Vries, A. P. J.</au><au>de Koning, E. J.</au><au>de Fijter, J. W.</au><au>Rabelink, T. J.</au><au>van Zonneveld, A. J.</au><au>Reinders, M. E. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2015-04</date><risdate>2015</risdate><volume>15</volume><issue>4</issue><spage>1081</spage><epage>1090</epage><pages>1081-1090</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Because microvascular disease is one of the most important drivers of diabetic complications, early monitoring of microvascular integrity may be of clinical value. By assessing profiles of circulating microRNAs (miRNAs), known regulators of microvascular pathophysiology, in healthy controls and diabetic nephropathy (DN) patients before and after simultaneous pancreas–kidney transplantation (SPK), we aimed to identify differentially expressed miRNAs that associate with microvascular impairment. Following a pilot study, we selected 13 candidate miRNAs and determined their circulating levels in DN (n = 21), SPK‐patients (n = 37), healthy controls (n = 19), type 1 diabetes mellitus patients (n = 15) and DN patients with a kidney transplant (n = 15). For validation of selected miRNAs, 14 DN patients were studied longitudinally up to 12 months after SPK. We demonstrated a direct association of miR‐25, ‐27a, ‐126, ‐130b, ‐132, ‐152, ‐181a, ‐223, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 with DN. Of those, miR‐25, ‐27a, ‐130b, ‐132, ‐152, ‐320, ‐326, ‐340, ‐574‐3p and ‐660 normalized after SPK. Importantly, circulating levels of some of these miRNAs tightly associate with microvascular impairment as they relate to aberrant capillary tortuosity, angiopoietin‐2/angiopoietin‐1 ratios, circulating levels of soluble‐thrombomodulin and insulin‐like growth factor. Taken together, circulating miRNA profiles associate with DN and systemic microvascular damage, and might serve to identify individuals at risk of experiencing microvascular complications, as well as give insight into underlying pathologies.
Selected circulating microRNAs correlate with diabetic nephropathy and systemic microvascular damage, and normalize after simultaneous pancreas–kidney transplantation, providing novel opportunities for the identification of patients at risk for microvascular complications and pathways involved in disease progression.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>25716422</pmid><doi>10.1111/ajt.13072</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2015-04, Vol.15 (4), p.1081-1090 |
| issn | 1600-6135 1600-6143 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1666727573 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescent Adult basic (laboratory) research/science biomarker clinical research/practice Diabetes diabetes: secondary complications Diabetic Nephropathies - blood Female Humans Kidney Transplantation kidney transplantation/nephrology Male MicroRNAs MicroRNAs - blood Middle Aged molecular biology: micro RNA Pancreas Pancreas Transplantation pancreas/simultaneous pancreas–kidney transplantation Transplants & implants vascular biology Young Adult |
| title | Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A30%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20MicroRNAs%20Associate%20With%20Diabetic%20Nephropathy%20and%20Systemic%20Microvascular%20Damage%20and%20Normalize%20After%20Simultaneous%20Pancreas%E2%80%93Kidney%20Transplantation&rft.jtitle=American%20journal%20of%20transplantation&rft.au=Bijkerk,%20R.&rft.date=2015-04&rft.volume=15&rft.issue=4&rft.spage=1081&rft.epage=1090&rft.pages=1081-1090&rft.issn=1600-6135&rft.eissn=1600-6143&rft_id=info:doi/10.1111/ajt.13072&rft_dat=%3Cproquest_cross%3E3629232011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1664598847&rft_id=info:pmid/25716422&rfr_iscdi=true |