Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet

BACKGROUND—This study was designed to evaluate the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet. METHODS AND RESULTS—Arglabin was purified, and its chemical identity was confirmed by mass spectrometry. It inhibite...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2015-03, Vol.131 (12), p.1061-1070
Hauptverfasser:	Abderrazak, Amna, Couchie, Dominique, Mahmood, Dler Faieeq Darweesh, Elhage, Rima, Vindis, Cécile, Laffargue, Muriel, Matéo, Véronique, Büchele, Berthold, Ayala, Monica Rubio, El Gaafary, Menna, Syrovets, Tatiana, Slimane, Mohamed-Naceur, Friguet, Bertrand, Fulop, Tamas, Simmet, Thomas, El Hadri, Khadija, Rouis, Mustapha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Apolipoprotein E2 - deficiency Atherosclerosis - blood Atherosclerosis - drug therapy Atherosclerosis - etiology Carrier Proteins - antagonists & inhibitors Diet, High-Fat - adverse effects Female Inflammasomes - antagonists & inhibitors Inflammasomes - metabolism Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Treatment Outcome
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