Effects on lung stress of position and different doses of perfluorocarbon in a model of ARDS

Highlights • Ventilator settings must take into account both gas exchange and stress and strain. • Combining PLV with optimal PEEP should improve gas exchange with minimal stress in supine position. • PFC can modify lung homogeneity and thus distort the beneficial effect of prone positioning.

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Veröffentlicht in:	Respiratory physiology & neurobiology 2015-05, Vol.210, p.30-37
Hauptverfasser:	López-Aguilar, Josefina, Lucangelo, Umberto, Albaiceta, Guillermo M, Nahum, Avi, Murias, Gastón, Cañizares, Rosario, Oliva, Joan Carles, Romero, Pablo V, Blanch, Lluís
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - physiopathology Acute Lung Injury - therapy Animals ARDS Blood Gas Analysis Cardiovascular Agents - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Fluorocarbons - pharmacology Hemodynamics - drug effects Hemodynamics - physiology Liquid Ventilation - methods Lung - drug effects Lung - physiopathology Lung recruitment Male Medical Education Oleic Acids - pharmacology Partial liquid ventilation Perfluorocarbon Positive-Pressure Respiration Prone Prone Position - physiology Pulmonary/Respiratory Respiration, Artificial Respiratory Distress Syndrome, Adult - physiopathology Respiratory Distress Syndrome, Adult - therapy Stress Stress, Physiological - drug effects Stress, Physiological - physiology Supine Position - physiology Swine
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Beschreibung
Zusammenfassung:	Highlights • Ventilator settings must take into account both gas exchange and stress and strain. • Combining PLV with optimal PEEP should improve gas exchange with minimal stress in supine position. • PFC can modify lung homogeneity and thus distort the beneficial effect of prone positioning.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2015.01.016