Intralesional vs. contact cryosurgery in treatment of keloids: a clinical and immunohistochemical study
Background Cryosurgery is a safe and effective treatment of keloids. Intralesional cryosurgery has been shown to bring about significant improvement in keloids. The histopathological and immunohistochemical changes in keloids following cryosurgery are not well‐assessed. Methods Twenty‐three patients...
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| Veröffentlicht in: | International journal of dermatology 2015-04, Vol.54 (4), p.468-475 |
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| container_title | International journal of dermatology |
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| creator | Abdel-Meguid, Azza M. Weshahy, Ahmed Hany Sayed, Doaa S. Refaiy, Abeer E.M. Awad, Sara M.I. |
| description | Background
Cryosurgery is a safe and effective treatment of keloids. Intralesional cryosurgery has been shown to bring about significant improvement in keloids. The histopathological and immunohistochemical changes in keloids following cryosurgery are not well‐assessed.
Methods
Twenty‐three patients with 66 keloids were treated with either the contact (cryoprobe) method or intralesional cryosurgery. Keloid specimens were obtained before treatment and after two sessions of treatment for evaluation of keloid pathology and immunohistochemical changes in expression of vascular endothelial growth factor (VEGF) and tenascin C induced by both cryosurgical techniques.
Results
A better therapeutic response was detected after intralesional cryosurgery (excellent response [ER], 87%) than contact cryosurgery (ER, 60%; P |
| doi_str_mv | 10.1111/ijd.12667 |
| format | Article |
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Cryosurgery is a safe and effective treatment of keloids. Intralesional cryosurgery has been shown to bring about significant improvement in keloids. The histopathological and immunohistochemical changes in keloids following cryosurgery are not well‐assessed.
Methods
Twenty‐three patients with 66 keloids were treated with either the contact (cryoprobe) method or intralesional cryosurgery. Keloid specimens were obtained before treatment and after two sessions of treatment for evaluation of keloid pathology and immunohistochemical changes in expression of vascular endothelial growth factor (VEGF) and tenascin C induced by both cryosurgical techniques.
Results
A better therapeutic response was detected after intralesional cryosurgery (excellent response [ER], 87%) than contact cryosurgery (ER, 60%; P < 0.05). The intralesional technique achieved higher rates of flattening after the first two sessions (ER in 61.3% and 22.9%, respectively; P < 0.05) and caused fewer side effects compared with the contact method. Both cryosurgical methods resulted in a significant decrease in VEGF and tenascin C expression in keloids.
Conclusions
Intralesional cryosurgery is superior to contact cryosurgery in terms of efficacy and safety. Both techniques may have beneficial effects on keloids, at least partially, through the modulation of VEGF and tenascin C expression.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.12667</identifier><identifier>PMID: 25442108</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Cryosurgery - methods ; Female ; Humans ; Immunohistochemistry ; Keloid - metabolism ; Keloid - pathology ; Keloid - surgery ; Male ; Middle Aged ; Tenascin - biosynthesis ; Young Adult</subject><ispartof>International journal of dermatology, 2015-04, Vol.54 (4), p.468-475</ispartof><rights>2014 The International Society of Dermatology</rights><rights>2014 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3637-b219ad2acc04ad333a5d7c9483f596bd465ba0b66f5d5975e3e391f6ce148dfa3</citedby><cites>FETCH-LOGICAL-c3637-b219ad2acc04ad333a5d7c9483f596bd465ba0b66f5d5975e3e391f6ce148dfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.12667$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.12667$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25442108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Meguid, Azza M.</creatorcontrib><creatorcontrib>Weshahy, Ahmed Hany</creatorcontrib><creatorcontrib>Sayed, Doaa S.</creatorcontrib><creatorcontrib>Refaiy, Abeer E.M.</creatorcontrib><creatorcontrib>Awad, Sara M.I.</creatorcontrib><title>Intralesional vs. contact cryosurgery in treatment of keloids: a clinical and immunohistochemical study</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Cryosurgery is a safe and effective treatment of keloids. Intralesional cryosurgery has been shown to bring about significant improvement in keloids. The histopathological and immunohistochemical changes in keloids following cryosurgery are not well‐assessed.
Methods
Twenty‐three patients with 66 keloids were treated with either the contact (cryoprobe) method or intralesional cryosurgery. Keloid specimens were obtained before treatment and after two sessions of treatment for evaluation of keloid pathology and immunohistochemical changes in expression of vascular endothelial growth factor (VEGF) and tenascin C induced by both cryosurgical techniques.
Results
A better therapeutic response was detected after intralesional cryosurgery (excellent response [ER], 87%) than contact cryosurgery (ER, 60%; P < 0.05). The intralesional technique achieved higher rates of flattening after the first two sessions (ER in 61.3% and 22.9%, respectively; P < 0.05) and caused fewer side effects compared with the contact method. Both cryosurgical methods resulted in a significant decrease in VEGF and tenascin C expression in keloids.
Conclusions
Intralesional cryosurgery is superior to contact cryosurgery in terms of efficacy and safety. Both techniques may have beneficial effects on keloids, at least partially, through the modulation of VEGF and tenascin C expression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cryosurgery - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keloid - metabolism</subject><subject>Keloid - pathology</subject><subject>Keloid - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Tenascin - biosynthesis</subject><subject>Young Adult</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1O3DAUha2qVRloF7wA8rJdZLDj2Jl0Vw1_UyEqED9SN5Zj34AhsanttOTtMQyw426se_2ds_gQ2qZkTvPs2lszp6UQ9Qc0o0zwohKs_IhmhFBaNIQ3G2gzxtu8spJWn9FGyauqpGQxQ9crl4LqIVrvVI__xTnW3iWlE9Zh8nEM1xAmbB1OAVQawCXsO3wHvbcm_sAK6946q3NWOYPtMIzO39iYvL6B4fke02imL-hTp_oIX1_eLXRxsH--PCqOfx-ulj-PC80Eq4u2pI0ypdKaVMowxhQ3tW6qBet4I1pTCd4q0grRccObmgMD1tBOaKDVwnSKbaFv69774P-OEJMcbNTQ98qBH6OkImsqmSAko9_XqA4-xgCdvA92UGGSlMgnrzJ7lc9eM7vzUju2A5g38lVkBnbXwH_bw_R-k1z92nutLNaJLAse3hIq3Mn8W3N5dXIozw5Ory5P_9Ryjz0CMzOTAQ</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Abdel-Meguid, Azza M.</creator><creator>Weshahy, Ahmed Hany</creator><creator>Sayed, Doaa S.</creator><creator>Refaiy, Abeer E.M.</creator><creator>Awad, Sara M.I.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Intralesional vs. contact cryosurgery in treatment of keloids: a clinical and immunohistochemical study</title><author>Abdel-Meguid, Azza M. ; Weshahy, Ahmed Hany ; Sayed, Doaa S. ; Refaiy, Abeer E.M. ; Awad, Sara M.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3637-b219ad2acc04ad333a5d7c9483f596bd465ba0b66f5d5975e3e391f6ce148dfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cryosurgery - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keloid - metabolism</topic><topic>Keloid - pathology</topic><topic>Keloid - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Tenascin - biosynthesis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Meguid, Azza M.</creatorcontrib><creatorcontrib>Weshahy, Ahmed Hany</creatorcontrib><creatorcontrib>Sayed, Doaa S.</creatorcontrib><creatorcontrib>Refaiy, Abeer E.M.</creatorcontrib><creatorcontrib>Awad, Sara M.I.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Meguid, Azza M.</au><au>Weshahy, Ahmed Hany</au><au>Sayed, Doaa S.</au><au>Refaiy, Abeer E.M.</au><au>Awad, Sara M.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intralesional vs. contact cryosurgery in treatment of keloids: a clinical and immunohistochemical study</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>54</volume><issue>4</issue><spage>468</spage><epage>475</epage><pages>468-475</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Cryosurgery is a safe and effective treatment of keloids. Intralesional cryosurgery has been shown to bring about significant improvement in keloids. The histopathological and immunohistochemical changes in keloids following cryosurgery are not well‐assessed.
Methods
Twenty‐three patients with 66 keloids were treated with either the contact (cryoprobe) method or intralesional cryosurgery. Keloid specimens were obtained before treatment and after two sessions of treatment for evaluation of keloid pathology and immunohistochemical changes in expression of vascular endothelial growth factor (VEGF) and tenascin C induced by both cryosurgical techniques.
Results
A better therapeutic response was detected after intralesional cryosurgery (excellent response [ER], 87%) than contact cryosurgery (ER, 60%; P < 0.05). The intralesional technique achieved higher rates of flattening after the first two sessions (ER in 61.3% and 22.9%, respectively; P < 0.05) and caused fewer side effects compared with the contact method. Both cryosurgical methods resulted in a significant decrease in VEGF and tenascin C expression in keloids.
Conclusions
Intralesional cryosurgery is superior to contact cryosurgery in terms of efficacy and safety. Both techniques may have beneficial effects on keloids, at least partially, through the modulation of VEGF and tenascin C expression.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25442108</pmid><doi>10.1111/ijd.12667</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2015-04, Vol.54 (4), p.468-475 |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adolescent Adult Cryosurgery - methods Female Humans Immunohistochemistry Keloid - metabolism Keloid - pathology Keloid - surgery Male Middle Aged Tenascin - biosynthesis Young Adult |
| title | Intralesional vs. contact cryosurgery in treatment of keloids: a clinical and immunohistochemical study |
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