Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88

[Display omitted] Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-04, Vol.25 (7), p.1448-1452
Hauptverfasser:	Dzierba, Carolyn D., Bi, Yingzhi, Dasgupta, Bireshwar, Hartz, Richard A., Ahuja, Vijay, Cianchetta, Giovanni, Kumi, Godwin, Dong, Li, Aleem, Saadat, Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Qiao, Ying, Wang, Jiancheng, Zhang, Yulian, Liu, Ying, Zipp, Greg, Liang, Zhi, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Grace, James, Wilson, Alan, Nouraldeen, Amr, Westphal, Ryan, Kimball, David, Carson, Kenneth, Bronson, Joanne J., Macor, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Amines - chemical synthesis Amines - chemistry Amines - pharmacology Dose-Response Relationship, Drug Drug Design Ethanolamines - chemical synthesis Ethanolamines - chemistry Ethanolamines - pharmacology GPR88 HEK293 Cells Humans Molecular Structure Phenyl amine Phenylglycinol Receptors, G-Protein-Coupled - agonists Schizophrenia Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!