Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene

Alterations in trafficking and increases in expression of the lysosomal proteases cathepsins B, D and L have been observed in transformed cells and malignant tumors, including human breast carcinoma. ras and the related rab proteins participate in the vesicular transport processes required for norma...

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