Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: Implications for activation of the protein kinase GCN2

The transcriptional activator protein GCN4 is responsible for increased transcription of more than 30 different amino acid biosynthetic genes in response to starvation for a single amino acid. This induction depends on increased expression of GCN4 at the translational level. We show that starvation...

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Veröffentlicht in:Molecular and cellular biology 1993-01, Vol.8 (13), p.5099-5111
Hauptverfasser: Rolfes, R J, Hinnebusch, A G
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Sprache:eng
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