Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization

Most seven-transmembrane G-protein-coupled receptors are rapidly internalized after binding agonist, but the general amino acid recognition sequences mediating this phenomenon have not been identified. In this study, components of the gastrin-releasing peptide receptor (GRP-R) regulating internaliza...

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Veröffentlicht in:	The Journal of biological chemistry 1993-09, Vol.268 (27), p.20285-20290
Hauptverfasser:	BENYA, R. V, FATHI, Z, BATTEY, J. F, JENSEN, R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive Biological and medical sciences Bombesin - metabolism Bombesin - pharmacology Cell receptors Cell structures and functions CHO Cells Cloning, Molecular Cricetinae DNA - genetics DNA - metabolism Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Inositol 1,4,5-Trisphosphate - metabolism Kinetics Mice Molecular and cellular biology Molecular Sequence Data Mutagenesis, Site-Directed Receptors, Bombesin Receptors, Neurotransmitter - biosynthesis Receptors, Neurotransmitter - genetics Receptors, Neurotransmitter - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Sequence Deletion Serine Threonine Transfection
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