Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

•EPA upregulated VEGF-A production in mature 3T3-L1 adipocytes.•GPR120 silencing or chemical inhibition of PPARγ attenuated the effect on VEGF-A.•GPR120 and PPARγ genes synergistically enhanced VEGF-A transcription in HEK293 cells.•GPR120 augmented PPARγ binding to PPRE in VEGF-A promoter region.•EP...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-05, Vol.406, p.10-18
Hauptverfasser:	Hasan, Arif U., Ohmori, Koji, Konishi, Kumi, Igarashi, Junsuke, Hashimoto, Takeshi, Kamitori, Kazuyo, Yamaguchi, Fuminori, Tsukamoto, Ikuko, Uyama, Toru, Ishihara, Yasuhiro, Noma, Takahisa, Tokuda, Masaaki, Kohno, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Animals Cytokines Diabetes Eicosapentaenoic Acid - pharmacology G proteins HEK293 Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Models, Biological Obesity Phosphatidylinositol 3-Kinases - metabolism PPAR gamma - metabolism Protein Binding - drug effects Protein Kinase C - metabolism Protein kinases/MAP kinase Receptors, G-Protein-Coupled - metabolism Response Elements - genetics Signal Transduction - drug effects Up-Regulation - drug effects Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism ω-3 fatty acids
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