Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones

The (+)-enantiomer of α-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (...

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Veröffentlicht in:	Neuropharmacology 1993-07, Vol.32 (7), p.725-727
Hauptverfasser:	Jane, D.E., Jones, P.L.St.J., Poor, P.C.-K., Salt, T.E., Sunter, D.C., Watkins, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Animals Animals, Newborn - physiology Benzoates - pharmacology Biological and medical sciences Cycloleucine - analogs & derivatives Cycloleucine - antagonists & inhibitors Cycloleucine - pharmacology Excitatory Amino Acid Antagonists Glycine - analogs & derivatives Glycine - pharmacology Ibotenic Acid - analogs & derivatives Ibotenic Acid - pharmacology MCPG Medical sciences metabotropic glutamate receptors Miscellaneous Motor Neurons - drug effects N-Methylaspartate - pharmacology Neuromuscular Depolarizing Agents - pharmacology Neurons - drug effects Neuropharmacology Neurotoxins - antagonists & inhibitors Neurotoxins - pharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats spinal cord Spinal Cord - cytology Spinal Cord - drug effects Stereoisomerism stereospecificity thalamus Thalamus - cytology Thalamus - drug effects
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