Adducts of Dienochlor Miticide with Glutathione, Glutathione S-Transferases, and Hemoglobins

Dienochlor (Pentac) (C10Cl10) has been used for 30 years as a miticide with little knowledge of its mode of action or metabolic fate except that it is quickly degraded by rats. This study examines the reactions of dienochlor with GSH and proteins as models for its metabolism and interactions with ti...

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Veröffentlicht in:	Chemical research in toxicology 1994-07, Vol.7 (4), p.487-494
Hauptverfasser:	Fruetel, Julia A, Sparks, Susan E, Quistad, Gary B, Casida, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cattle Chloranil - chemistry Cyclopentanes - chemistry Glutathione - chemistry Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - chemistry Glutathione Transferase - metabolism Hemoglobins - chemistry Horses Humans Hydrocarbons, Chlorinated - chemistry Hydrocarbons, Chlorinated - metabolism Hydrocarbons, Chlorinated - toxicity Insecticides - chemistry Insecticides - metabolism Insecticides - toxicity Lethal Dose 50 Liver - drug effects Liver - enzymology Liver - metabolism Male Medical sciences Mice Pesticides, fertilizers and other agrochemicals toxicology Rabbits Rats Species Specificity Swine Toxicology
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