Micronucleus formation in cultured human keratinocytes following exposure to mitomycin C and cyclophosphamide

A method is described to investigate the induction of micronuclei in cultured human keratinocytes after short-term exposure to known clastogenic agents. The cytokinesis-block method was applied to facilitate the scoring of micronucleated cells. Mitomycin C, a direct-acting compound, caused a 5–20-fo...

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Veröffentlicht in:	Mutation Research 1991-02, Vol.252 (1), p.45-50
Hauptverfasser:	van Pelt, Frank N.A.M., Haring, RenéM., Overkamp, Miep J.I., Weterings, Peter J.J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Aroclor 1254 Aroclors - pharmacology Biological and medical sciences Cells, Cultured Chlorodiphenyl (54% Chlorine) Cultured human keratinocytes Cyclophosphamide Cyclophosphamide - pharmacology Cytochrome P450 Dose-Response Relationship, Drug Drug Synergism Drug toxicity and drugs side effects treatment Humans In Vitro Techniques keratinocytes Keratinocytes - drug effects Male man Medical sciences micronuclei Micronucleus Tests Micronucleus, in vitro Miscellaneous (drug allergy, mutagens, teratogens...) Mitomycin Mitomycin C Mitomycins - pharmacology Pharmacology. Drug treatments Time Factors
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