Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input

•Glutamate decreases [3H]-GABA uptake in Müller glia via ionotropic receptors.•Glutamate increases intracellular Ca2+without causing toxicity to Müller cells.•GAT-1 and GAT-3 mRNA levels are also decreased by glutamate.•Inhibition on GAT-3 activity is not reverted by PKC inhibitors.•Intra-vitreous i...

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Veröffentlicht in:	Neurochemistry international 2015-03, Vol.82, p.42-51
Hauptverfasser:	Schitine, Clarissa S., Mendez-Flores, Orquidia G., Santos, Luis E., Ornelas, Isis, Calaza, Karin C., Pérez-Toledo, Karla, López-Bayghen, Esther, Ortega, Arturo, Gardino, Patrícia F., de Mello, Fernando G., Reis, Ricardo A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active Biotinylation Calcium - analysis Cell Membrane - metabolism Cells, Cultured Chick Embryo Chickens Culture Media, Conditioned Ependymoglial Cells - drug effects Ependymoglial Cells - physiology GABA Plasma Membrane Transport Proteins - genetics GABA Plasma Membrane Transport Proteins - physiology GABA transporters gamma-Aminobutyric Acid - metabolism Gene Expression Profiling Glutamate receptors Glutamic Acid - pharmacology Glutamic Acid - physiology Kainic Acid - pharmacology Müller glia N-Methylaspartate - administration & dosage N-Methylaspartate - pharmacology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Protein Kinase Inhibitors - pharmacology Retina - growth & development RNA, Messenger - biosynthesis RNA, Messenger - genetics Tetradecanoylphorbol Acetate - pharmacology
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