Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee Osteoarthritis
Background Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA. Met...
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| Veröffentlicht in: | Journal of investigative medicine 2015-04, Vol.63 (4), p.626-631 |
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| container_title | Journal of investigative medicine |
| container_volume | 63 |
| creator | Huo, Li Wei Ye, Yong Liang Wang, Guang Wei Ye, Yong Guang |
| description | Background
Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.
Method
One hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.
Results
Fractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.
Conclusions
Fractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study. |
| doi_str_mv | 10.1097/JIM.0000000000000158 |
| format | Article |
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Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.
Method
One hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.
Results
Fractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.
Conclusions
Fractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study.</description><identifier>ISSN: 1081-5589</identifier><identifier>EISSN: 1708-8267</identifier><identifier>DOI: 10.1097/JIM.0000000000000158</identifier><identifier>PMID: 25692263</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Biomarkers - blood ; Case-Control Studies ; Chemokine CX3CL1 - blood ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee - blood ; Osteoarthritis, Knee - diagnosis ; Severity of Illness Index ; Synovial Fluid - metabolism</subject><ispartof>Journal of investigative medicine, 2015-04, Vol.63 (4), p.626-631</ispartof><rights>2015 American Federation for Medical Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-9d292954deaa1f0693f9af9cd9e5a9886ad3f719d527c2f472a75d534820e8743</citedby><cites>FETCH-LOGICAL-c400t-9d292954deaa1f0693f9af9cd9e5a9886ad3f719d527c2f472a75d534820e8743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/JIM.0000000000000158$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/JIM.0000000000000158$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25692263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, Li Wei</creatorcontrib><creatorcontrib>Ye, Yong Liang</creatorcontrib><creatorcontrib>Wang, Guang Wei</creatorcontrib><creatorcontrib>Ye, Yong Guang</creatorcontrib><title>Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee Osteoarthritis</title><title>Journal of investigative medicine</title><addtitle>J Investig Med</addtitle><description>Background
Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.
Method
One hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.
Results
Fractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.
Conclusions
Fractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chemokine CX3CL1 - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis, Knee - blood</subject><subject>Osteoarthritis, Knee - diagnosis</subject><subject>Severity of Illness Index</subject><subject>Synovial Fluid - metabolism</subject><issn>1081-5589</issn><issn>1708-8267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0E4v0HCHkJi4DtxC92UPEuAlGQ2EUmGYPbNCm2C-rfY9SCEAtmM6PRuXc0F6EdSg4o0fLw6vLmgPwuytUSWqeSqEwxIZfTTBTNOFd6DW2EMCSECa7ZKlpjXGjGRL6O7Jk3VTTNyLWA93pPea9P94_wMT5x3dj4EXh8D7aBKrr2BQ9m40lM--gqPIB38C7OsGvxXdpAGwP-cPEVX7cA-DZE6IyPr4lxYQutWNME2F70TfR4dvrQu8j6t-eXveN-VhWExEzXTDPNixqMoZYInVttrK5qDdxopYSpcyuprjmTFbOFZEbymueFYgSULPJNtDf3nfjubQohlmMXKmga00I3DSUVghdacKkTWszRyncheLDlxLv08qykpPxKuEwJl38TTrLdxYXp8xjqH9F3pAmgcyCYFyiH3dS36eP_TT8B-4SD-A</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Huo, Li Wei</creator><creator>Ye, Yong Liang</creator><creator>Wang, Guang Wei</creator><creator>Ye, Yong Guang</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee Osteoarthritis</title><author>Huo, Li Wei ; Ye, Yong Liang ; Wang, Guang Wei ; Ye, Yong Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-9d292954deaa1f0693f9af9cd9e5a9886ad3f719d527c2f472a75d534820e8743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chemokine CX3CL1 - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis, Knee - blood</topic><topic>Osteoarthritis, Knee - diagnosis</topic><topic>Severity of Illness Index</topic><topic>Synovial Fluid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Li Wei</creatorcontrib><creatorcontrib>Ye, Yong Liang</creatorcontrib><creatorcontrib>Wang, Guang Wei</creatorcontrib><creatorcontrib>Ye, Yong Guang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Li Wei</au><au>Ye, Yong Liang</au><au>Wang, Guang Wei</au><au>Ye, Yong Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee Osteoarthritis</atitle><jtitle>Journal of investigative medicine</jtitle><addtitle>J Investig Med</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>63</volume><issue>4</issue><spage>626</spage><epage>631</epage><pages>626-631</pages><issn>1081-5589</issn><eissn>1708-8267</eissn><abstract>Background
Elevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.
Method
One hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.
Results
Fractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.
Conclusions
Fractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>25692263</pmid><doi>10.1097/JIM.0000000000000158</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1081-5589 |
| ispartof | Journal of investigative medicine, 2015-04, Vol.63 (4), p.626-631 |
| issn | 1081-5589 1708-8267 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1665496579 |
| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Aged Biomarkers - blood Case-Control Studies Chemokine CX3CL1 - blood Female Humans Male Middle Aged Osteoarthritis, Knee - blood Osteoarthritis, Knee - diagnosis Severity of Illness Index Synovial Fluid - metabolism |
| title | Fractalkine (CX3CL1): A Biomarker Reflecting Symptomatic Severity in Patients with Knee Osteoarthritis |
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