Carbosilane dendrimers inhibit α-synuclein fibrillation and prevent cells from rotenone-induced damage

[Display omitted] This study investigates the role of carbosilane dendrimers in fibrillation of α-synuclein and prevention of the mouse hippocampal cell (mHippoE-18) from rotenone-induced damage. Examining the interaction between carbosilane dendrimers and α-synuclein, we found that the dendrimers i...

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Veröffentlicht in:	International journal of pharmaceutics 2015-04, Vol.484 (1-2), p.268-275
Hauptverfasser:	Milowska, Katarzyna, Szwed, Aleksandra, Mutrynowska, Marta, Gomez-Ramirez, Rafael, de la Mata, Francisco Javier, Gabryelak, Teresa, Bryszewska, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - antagonists & inhibitors alpha-Synuclein - metabolism Animals Carbosilane dendrimers Cell Line Cell Survival - drug effects Cell Survival - physiology Dendrimers - pharmacology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Mice Parkinson’s disease Reactive Oxygen Species - metabolism Rotenone Rotenone - toxicity Silanes - pharmacology α-Synuclein
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