Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces

Exposure of phosphatidylserine (PS) molecules on activated platelet membrane surface is a crucial event in blood coagulation. Binding of PS to specific sites on factor Xa (fXa) and factor Va (fVa) promotes their assembly into a complex that enhances proteolysis of prothrombin by approximately 10⁵. R...

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Veröffentlicht in:	Biochemical journal 2015-04, Vol.467 (1), p.37-46
Hauptverfasser:	Koklic, Tilen, Chattopadhyay, Rima, Majumder, Rinku, Lentz, Barry R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Binding, Competitive Blood Coagulation Blood Platelets - metabolism Calcium Signaling Catalytic Domain Cattle Cell Membrane - metabolism Dimerization Factor V - chemistry Factor V - metabolism Factor Xa - chemistry Factor Xa - metabolism Histidine - analogs & derivatives Histidine - chemistry Humans Kinetics Models, Biological Phosphatidylserines - metabolism Platelet Activation Protein Interaction Domains and Motifs Protein Multimerization
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