Building a better mousetrap II: Using Design of Experiments with unconfounded ions to compare the growth of different microalgae
•Unconfounded media variations were used to examine microalgal growth.•The effects of variations in NH4+, NO3−, Na+, K+, PO4−, and Cl− were studied.•Two strains of Chlorella show significant physiological and functional differences.•Different microalgae show different effects for growth and lipid co...
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| Veröffentlicht in: | Bioresource technology 2015-05, Vol.184, p.90-99 |
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| creator | Hallenbeck, Patrick C. Grogger, Melanie Mraz, Megan Veverka, Donald |
| description | •Unconfounded media variations were used to examine microalgal growth.•The effects of variations in NH4+, NO3−, Na+, K+, PO4−, and Cl− were studied.•Two strains of Chlorella show significant physiological and functional differences.•Different microalgae show different effects for growth and lipid content.•Future work could lead to the development of novel media.
A large number of unconfounded media variations were used with a Scheffe Mix Model to examine in an unambiguous fashion the effects of variations in six important ions; NH4+, NO3−, Na+, K+, PO4−, and Cl−, on the growth of Chlorella vulgaris. This allows several novel observations on media components, for example, the inhibitory effects of chloride, to be made. Using a side by side comparison, it is shown that two strains of Chlorella show significant physiological and functional differences brought out by this approach. Testing selected formulations with a diverse set of algae demonstrated different effects on both growth and cellular lipid content, in some cases driving significant lipid production. This suggests that future work using a larger portion of media composition space could lead to the development of novel media supporting maximal biomass production and lipid production. |
| doi_str_mv | 10.1016/j.biortech.2014.11.006 |
| format | Article |
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A large number of unconfounded media variations were used with a Scheffe Mix Model to examine in an unambiguous fashion the effects of variations in six important ions; NH4+, NO3−, Na+, K+, PO4−, and Cl−, on the growth of Chlorella vulgaris. This allows several novel observations on media components, for example, the inhibitory effects of chloride, to be made. Using a side by side comparison, it is shown that two strains of Chlorella show significant physiological and functional differences brought out by this approach. Testing selected formulations with a diverse set of algae demonstrated different effects on both growth and cellular lipid content, in some cases driving significant lipid production. This suggests that future work using a larger portion of media composition space could lead to the development of novel media supporting maximal biomass production and lipid production.</description><identifier>ISSN: 0960-8524</identifier><identifier>EISSN: 1873-2976</identifier><identifier>DOI: 10.1016/j.biortech.2014.11.006</identifier><identifier>PMID: 25465789</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Algae ; Ammonium Compounds - pharmacology ; Biofuels ; Chlorella vulgaris - growth & development ; Ions ; Lipids - biosynthesis ; Medium optimization unconfounded ions ; Microalgae - drug effects ; Microalgae - growth & development ; Nitrates - pharmacology ; Potassium - pharmacology ; Research Design ; Response surface methodology ; Scheffe Mix Model ; Solutions</subject><ispartof>Bioresource technology, 2015-05, Vol.184, p.90-99</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-8f1ff3884cefb8d2eca613b09fde30dc388bd2d98b47b64561881037a80d2cff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biortech.2014.11.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25465789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallenbeck, Patrick C.</creatorcontrib><creatorcontrib>Grogger, Melanie</creatorcontrib><creatorcontrib>Mraz, Megan</creatorcontrib><creatorcontrib>Veverka, Donald</creatorcontrib><title>Building a better mousetrap II: Using Design of Experiments with unconfounded ions to compare the growth of different microalgae</title><title>Bioresource technology</title><addtitle>Bioresour Technol</addtitle><description>•Unconfounded media variations were used to examine microalgal growth.•The effects of variations in NH4+, NO3−, Na+, K+, PO4−, and Cl− were studied.•Two strains of Chlorella show significant physiological and functional differences.•Different microalgae show different effects for growth and lipid content.•Future work could lead to the development of novel media.
A large number of unconfounded media variations were used with a Scheffe Mix Model to examine in an unambiguous fashion the effects of variations in six important ions; NH4+, NO3−, Na+, K+, PO4−, and Cl−, on the growth of Chlorella vulgaris. This allows several novel observations on media components, for example, the inhibitory effects of chloride, to be made. Using a side by side comparison, it is shown that two strains of Chlorella show significant physiological and functional differences brought out by this approach. Testing selected formulations with a diverse set of algae demonstrated different effects on both growth and cellular lipid content, in some cases driving significant lipid production. This suggests that future work using a larger portion of media composition space could lead to the development of novel media supporting maximal biomass production and lipid production.</description><subject>Algae</subject><subject>Ammonium Compounds - pharmacology</subject><subject>Biofuels</subject><subject>Chlorella vulgaris - growth & development</subject><subject>Ions</subject><subject>Lipids - biosynthesis</subject><subject>Medium optimization unconfounded ions</subject><subject>Microalgae - drug effects</subject><subject>Microalgae - growth & development</subject><subject>Nitrates - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Research Design</subject><subject>Response surface methodology</subject><subject>Scheffe Mix Model</subject><subject>Solutions</subject><issn>0960-8524</issn><issn>1873-2976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAURS1ERYeWX6i8ZJNgO4njsAJKgZEqddOuLcd-nvEosYPttLDj0_FoWrasvHjnvud7ELqipKaE8g-HenQhZtD7mhHa1pTWhPBXaENF31Rs6PlrtCEDJ5XoWHuO3qZ0IIQ0tGdv0DnrWt71YtigP19WNxnnd1jhEXKGiOewJshRLXi7_Ygf0nH4FZLbeRwsvvm1QHQz-Jzwk8t7vHodvA2rN2CwCz7hHLAO86Ii4LwHvIvhqXAla5y1EEsUz07HoKadgkt0ZtWU4N3ze4Eevt3cX_-obu--b68_31a6ZSxXwlJrGyFaDXYUhoFWnDYjGayBhhhdRqNhZhBj24-87TgVgpKmV4IYpkv0Ar0_7V1i-LlCynJ2ScM0KQ-lsKScd-3Q0b4pKD-h5Y8pRbByKY1V_C0pkUf78iBf7MujfUmpLPZL8Or5xjrOYP7FXnQX4NMJgNL00UGUSTvwGoyLoLM0wf3vxl8Mjpwi</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Hallenbeck, Patrick C.</creator><creator>Grogger, Melanie</creator><creator>Mraz, Megan</creator><creator>Veverka, Donald</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Building a better mousetrap II: Using Design of Experiments with unconfounded ions to compare the growth of different microalgae</title><author>Hallenbeck, Patrick C. ; Grogger, Melanie ; Mraz, Megan ; Veverka, Donald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8f1ff3884cefb8d2eca613b09fde30dc388bd2d98b47b64561881037a80d2cff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Algae</topic><topic>Ammonium Compounds - pharmacology</topic><topic>Biofuels</topic><topic>Chlorella vulgaris - growth & development</topic><topic>Ions</topic><topic>Lipids - biosynthesis</topic><topic>Medium optimization unconfounded ions</topic><topic>Microalgae - drug effects</topic><topic>Microalgae - growth & development</topic><topic>Nitrates - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Research Design</topic><topic>Response surface methodology</topic><topic>Scheffe Mix Model</topic><topic>Solutions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallenbeck, Patrick C.</creatorcontrib><creatorcontrib>Grogger, Melanie</creatorcontrib><creatorcontrib>Mraz, Megan</creatorcontrib><creatorcontrib>Veverka, Donald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioresource technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallenbeck, Patrick C.</au><au>Grogger, Melanie</au><au>Mraz, Megan</au><au>Veverka, Donald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Building a better mousetrap II: Using Design of Experiments with unconfounded ions to compare the growth of different microalgae</atitle><jtitle>Bioresource technology</jtitle><addtitle>Bioresour Technol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>184</volume><spage>90</spage><epage>99</epage><pages>90-99</pages><issn>0960-8524</issn><eissn>1873-2976</eissn><abstract>•Unconfounded media variations were used to examine microalgal growth.•The effects of variations in NH4+, NO3−, Na+, K+, PO4−, and Cl− were studied.•Two strains of Chlorella show significant physiological and functional differences.•Different microalgae show different effects for growth and lipid content.•Future work could lead to the development of novel media.
A large number of unconfounded media variations were used with a Scheffe Mix Model to examine in an unambiguous fashion the effects of variations in six important ions; NH4+, NO3−, Na+, K+, PO4−, and Cl−, on the growth of Chlorella vulgaris. This allows several novel observations on media components, for example, the inhibitory effects of chloride, to be made. Using a side by side comparison, it is shown that two strains of Chlorella show significant physiological and functional differences brought out by this approach. Testing selected formulations with a diverse set of algae demonstrated different effects on both growth and cellular lipid content, in some cases driving significant lipid production. This suggests that future work using a larger portion of media composition space could lead to the development of novel media supporting maximal biomass production and lipid production.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25465789</pmid><doi>10.1016/j.biortech.2014.11.006</doi><tpages>10</tpages></addata></record> |
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| ispartof | Bioresource technology, 2015-05, Vol.184, p.90-99 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Algae Ammonium Compounds - pharmacology Biofuels Chlorella vulgaris - growth & development Ions Lipids - biosynthesis Medium optimization unconfounded ions Microalgae - drug effects Microalgae - growth & development Nitrates - pharmacology Potassium - pharmacology Research Design Response surface methodology Scheffe Mix Model Solutions |
| title | Building a better mousetrap II: Using Design of Experiments with unconfounded ions to compare the growth of different microalgae |
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