γ-Oryzanol Protects Pancreatic β-Cells Against Endoplasmic Reticulum Stress in Male Mice

Endoplasmic reticulum (ER) stress is profoundly involved in dysfunction of β-cells under high-fat diet and hyperglycemia. Our recent study in mice showed that γ-oryzanol, a unique component of brown rice, acts as a chemical chaperone in the hypothalamus and improves feeding behavior and diet-induced...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2015-04, Vol.156 (4), p.1242-1250
Hauptverfasser:	Kozuka, Chisayo, Sunagawa, Sumito, Ueda, Rei, Higa, Moritake, Tanaka, Hideaki, Shimizu-Okabe, Chigusa, Ishiuchi, Shogo, Takayama, Chitoshi, Matsushita, Masayuki, Tsutsui, Masato, Miyazaki, Jun-ichi, Oyadomari, Seiichi, Shimabukuro, Michio, Masuzaki, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Beta cells Cell Line Cell survival Cell Survival - drug effects Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diet Diet, High-Fat Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Feeding behavior Genes Glucose Glucose metabolism High fat diet Hyperglycemia Hypothalamus Insulin Insulin - metabolism Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Mice mRNA Oral administration Pancreas Phenylpropionates - pharmacology Phosphorylation Streptozocin Stress Tunicamycin
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