Aberrant Cerebellar Development of Transgenic Mice Expressing Dominant-Negative Thyroid Hormone Receptor in Cerebellar Purkinje Cells

To study the role of the thyroid hormone (TH) in cerebellar development, we generated transgenic mice expressing a dominant-negative TH receptor (TR) in cerebellar Purkinje cells. A mutant human TRβ1 (G345R), which binds to the TH-response element but cannot bind to T3, was subcloned into exon 4 of...

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