Synthesis of Pyrido[2,1‑b]quinazolin-11-ones and Dipyrido[1,2-a:2′,3′‑d]pyrimidin-5-ones by Pd/DIBPP-Catalyzed Dearomatizing Carbonylation
N-Fused heterocycles can be easily synthesized by palladium-catalyzed dearomatizing carbonylation using 1,3-bis(diisobutylphosphino)propane (DIBPP) as the ligand. Pyrido[2,1-b]quinazolin-11-ones were obtained from N-(2-bromophenyl)pyridine-2-amines in up to quantitative yield and dipyrido[1,2-a:2′,3...
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| Veröffentlicht in: | Organic letters 2015-03, Vol.17 (6), p.1569-1572 |
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| container_title | Organic letters |
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| creator | Xu, Tongyu Alper, Howard |
| description | N-Fused heterocycles can be easily synthesized by palladium-catalyzed dearomatizing carbonylation using 1,3-bis(diisobutylphosphino)propane (DIBPP) as the ligand. Pyrido[2,1-b]quinazolin-11-ones were obtained from N-(2-bromophenyl)pyridine-2-amines in up to quantitative yield and dipyrido[1,2-a:2′,3′-d]pyrimidin-5-ones from 3-bromo-N-(pyridine-2-yl)pyridine-2-amines in up to 84% yield. The cyclocarbonylation can be also realized without isolation of compound 1 and additional palladium catalyst. |
| doi_str_mv | 10.1021/acs.orglett.5b00452 |
| format | Article |
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Pyrido[2,1-b]quinazolin-11-ones were obtained from N-(2-bromophenyl)pyridine-2-amines in up to quantitative yield and dipyrido[1,2-a:2′,3′-d]pyrimidin-5-ones from 3-bromo-N-(pyridine-2-yl)pyridine-2-amines in up to 84% yield. 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| source | ACS Publications |
| title | Synthesis of Pyrido[2,1‑b]quinazolin-11-ones and Dipyrido[1,2-a:2′,3′‑d]pyrimidin-5-ones by Pd/DIBPP-Catalyzed Dearomatizing Carbonylation |
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