Secondary Adrenocortical Insufficiency Complicated by Marked Hypercalcemia and Eosinophilia: A Case Report
A 56 year old female was admitted to a local hospital after developing symptoms, including generalized fatigue, nausea and vomiting, from trauma. She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her enti...
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| Veröffentlicht in: | Journal of UOEH 2015/03/01, Vol.37(1), pp.55-60 |
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| creator | YAMAMOTO, Sunao OKADA, Yosuke ARAO, Tadashi TANAKA, Yoshiya |
| description | A 56 year old female was admitted to a local hospital after developing symptoms, including generalized fatigue, nausea and vomiting, from trauma. She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her entire body. Her clinical symptoms (disturbance of consciousness, loss of appetite, nausea, vomiting, decrease in blood pressure, fever) and examination findings (low blood cortisol levels (1.2 μg/dl ), hypercalcemia (11.0 mg/dl ), peripheral blood eosinophilia (1,600 /μl )) lead to a diagnosis of adrenal insufficiency. In addition, a skin biopsy indicated eosinophilic infiltration, although her condition improved in the end with an oral dose of 30 mg/day of prednisolone. Hypercalcemia and peripheral blood eosinophilia are commonly known examination findings for adrenocortical insufficiency, but it is rare for either of these to be present as clinical symptoms. |
| doi_str_mv | 10.7888/juoeh.37.55 |
| format | Article |
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She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her entire body. Her clinical symptoms (disturbance of consciousness, loss of appetite, nausea, vomiting, decrease in blood pressure, fever) and examination findings (low blood cortisol levels (1.2 μg/dl ), hypercalcemia (11.0 mg/dl ), peripheral blood eosinophilia (1,600 /μl )) lead to a diagnosis of adrenal insufficiency. In addition, a skin biopsy indicated eosinophilic infiltration, although her condition improved in the end with an oral dose of 30 mg/day of prednisolone. 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She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her entire body. Her clinical symptoms (disturbance of consciousness, loss of appetite, nausea, vomiting, decrease in blood pressure, fever) and examination findings (low blood cortisol levels (1.2 μg/dl ), hypercalcemia (11.0 mg/dl ), peripheral blood eosinophilia (1,600 /μl )) lead to a diagnosis of adrenal insufficiency. In addition, a skin biopsy indicated eosinophilic infiltration, although her condition improved in the end with an oral dose of 30 mg/day of prednisolone. Hypercalcemia and peripheral blood eosinophilia are commonly known examination findings for adrenocortical insufficiency, but it is rare for either of these to be present as clinical symptoms.</description><subject>Addison Disease - complications</subject><subject>Addison Disease - diagnosis</subject><subject>Addison Disease - drug therapy</subject><subject>adrenocortical insufficiency</subject><subject>Consciousness Disorders - etiology</subject><subject>Diagnosis, Differential</subject><subject>eosinophilia</subject><subject>Eosinophilia - drug therapy</subject><subject>Eosinophilia - etiology</subject><subject>Exanthema - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>hypercalcemia</subject><subject>Hypercalcemia - drug therapy</subject><subject>Hypercalcemia - etiology</subject><subject>Middle Aged</subject><subject>Prednisolone - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0387-821X</issn><issn>2187-2864</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtqGzEUQEVpaUyaVfdFy0Kxo8foMV0UjEmTQEKhD-hOaO7cqeXOjKaSZ-G_rxInzkoX6ejAPYS852xlrLWXuznidiXNSqlXZCG4NUthdfWaLJgssxX89xm5yDk0jLFaGlmxt-RMKGMNZ3JBdj8Q4tj6dKDrNuEYIaZ9AN_T2zHPXRcg4AgHuonD1Jf7Pba0OdB7n_6W6eYwYSow4BA89WNLr2IOY5y2oQ_-M13Tjc9Iv-NUrO_Im873GS-eznPy6-vVz83N8u7b9e1mfbcEUWu1NNDxslmFIJiW0jam0h3XTPFaqFo3YLUA9N5AbZBLAXVlvdc1ogVZPshz8vHonVL8N2PeuyFkwL73I8Y5O6614oLLShf00xGFFHNO2LkphaHEcJy5h77usa-TxilV6A9P4rkZsD2xzzUL8OUI7PLe_8ET4B-S9vgi40fj6QG2Pjkc5X_S1I4e</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>YAMAMOTO, Sunao</creator><creator>OKADA, Yosuke</creator><creator>ARAO, Tadashi</creator><creator>TANAKA, Yoshiya</creator><general>The University of Occupational and Environmental Health, Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Secondary Adrenocortical Insufficiency Complicated by Marked Hypercalcemia and Eosinophilia: A Case Report</title><author>YAMAMOTO, Sunao ; OKADA, Yosuke ; ARAO, Tadashi ; TANAKA, Yoshiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2965-7cf18884ec206338b746f1605192596bc862ceaa7c97e132c948aa69ee8c36333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2015</creationdate><topic>Addison Disease - complications</topic><topic>Addison Disease - diagnosis</topic><topic>Addison Disease - drug therapy</topic><topic>adrenocortical insufficiency</topic><topic>Consciousness Disorders - etiology</topic><topic>Diagnosis, Differential</topic><topic>eosinophilia</topic><topic>Eosinophilia - drug therapy</topic><topic>Eosinophilia - etiology</topic><topic>Exanthema - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>hypercalcemia</topic><topic>Hypercalcemia - drug therapy</topic><topic>Hypercalcemia - etiology</topic><topic>Middle Aged</topic><topic>Prednisolone - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>YAMAMOTO, Sunao</creatorcontrib><creatorcontrib>OKADA, Yosuke</creatorcontrib><creatorcontrib>ARAO, Tadashi</creatorcontrib><creatorcontrib>TANAKA, Yoshiya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of UOEH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMAMOTO, Sunao</au><au>OKADA, Yosuke</au><au>ARAO, Tadashi</au><au>TANAKA, Yoshiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary Adrenocortical Insufficiency Complicated by Marked Hypercalcemia and Eosinophilia: A Case Report</atitle><jtitle>Journal of UOEH</jtitle><addtitle>J UOEH</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>37</volume><issue>1</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0387-821X</issn><eissn>2187-2864</eissn><abstract>A 56 year old female was admitted to a local hospital after developing symptoms, including generalized fatigue, nausea and vomiting, from trauma. She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her entire body. Her clinical symptoms (disturbance of consciousness, loss of appetite, nausea, vomiting, decrease in blood pressure, fever) and examination findings (low blood cortisol levels (1.2 μg/dl ), hypercalcemia (11.0 mg/dl ), peripheral blood eosinophilia (1,600 /μl )) lead to a diagnosis of adrenal insufficiency. In addition, a skin biopsy indicated eosinophilic infiltration, although her condition improved in the end with an oral dose of 30 mg/day of prednisolone. Hypercalcemia and peripheral blood eosinophilia are commonly known examination findings for adrenocortical insufficiency, but it is rare for either of these to be present as clinical symptoms.</abstract><cop>Japan</cop><pub>The University of Occupational and Environmental Health, Japan</pub><pmid>25787103</pmid><doi>10.7888/juoeh.37.55</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Addison Disease - complications Addison Disease - diagnosis Addison Disease - drug therapy adrenocortical insufficiency Consciousness Disorders - etiology Diagnosis, Differential eosinophilia Eosinophilia - drug therapy Eosinophilia - etiology Exanthema - etiology Female Humans hypercalcemia Hypercalcemia - drug therapy Hypercalcemia - etiology Middle Aged Prednisolone - administration & dosage Treatment Outcome |
| title | Secondary Adrenocortical Insufficiency Complicated by Marked Hypercalcemia and Eosinophilia: A Case Report |
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