Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

A clinical trial in patients with glioblastoma shows increased immune and anti-tumour responses to dendritic cell vaccination after pre-conditioning the site of vaccination with tetanus toxoid (Td); similar results are also seen in mice in part due to the actions of the chemokine CCL3, and the findi...

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Veröffentlicht in:	Nature (London) 2015-03, Vol.519 (7543), p.366-369
Hauptverfasser:	Mitchell, Duane A., Batich, Kristen A., Gunn, Michael D., Huang, Min-Nung, Sanchez-Perez, Luis, Nair, Smita K., Congdon, Kendra L., Reap, Elizabeth A., Archer, Gary E., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon II, James E., Coan, April, McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., Sampson, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/251/1567 631/67/1922 Animals Antigens, Neoplasm - immunology Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell Movement - drug effects Chemokine CCL3 - immunology Chemokines Clinical trials Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Female Glioblastoma - drug therapy Glioblastoma - immunology Glioblastoma - pathology Glioblastoma - therapy Glioblastoma multiforme Humanities and Social Sciences Humans Immunization Immunotherapy Immunotherapy - methods letter Lymph nodes Lymph Nodes - cytology Lymph Nodes - drug effects Lymph Nodes - immunology Lymphocytes Medical prognosis Medical research Medicine, Experimental Mice Mice, Inbred C57BL multidisciplinary Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - immunology Physiological aspects Science Substrate Specificity Survival Rate Tetanus Tetanus Toxoid - administration & dosage Tetanus Toxoid - pharmacology Tetanus Toxoid - therapeutic use Treatment Outcome Tumors Vaccines Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology
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