Trop2: From development to disease

Background: Trop2 was first discovered as a biomarker of invasive trophoblast cells. Since then most research has focused on its role in tumourigenesis because it is highly expressed in the vast majority of human tumours and animal models of cancer. It is also highly expressed in stem cells and in m...

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Veröffentlicht in:	Developmental dynamics 2015-02, Vol.244 (2), p.99-109
Hauptverfasser:	McDougall, Annie R.A., Tolcos, Mary, Hooper, Stuart B., Cole, Timothy J., Wallace, Megan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism cancer Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism cell migration Cell Movement - genetics cell proliferation Cell Proliferation - genetics Connexins - genetics Connexins - metabolism Corneal Dystrophies, Hereditary - genetics Corneal Dystrophies, Hereditary - metabolism EpCAM Gap Junction beta-1 Protein Humans lung development Mice Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Signal Transduction - genetics Tacstd2
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