Calcium ionophore-induced transient down-regulation of c-myb mRNA levels in Friend erythroleukemia cells

The effects of calcium ionophores A23187 and ionomycin on the c-myb and c-myc mRNA levels have been investigated in the Friend erythroleukemia cell line F4-6 using Northern blot analysis. Treatment of the cells with 0.5-4 microM A23187 or 1-4 microM ionomycin induced a concentration-dependent decrea...

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Veröffentlicht in:	The Journal of biological chemistry 1993-05, Vol.268 (15), p.10876-10880
Hauptverfasser:	Schaefer, A., Stöcker, U., Marquardt, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Animals Biological and medical sciences Blotting, Northern Calcimycin - pharmacology Cell Survival - drug effects Dimethyl Sulfoxide - pharmacology Egtazic Acid - pharmacology Friend murine leukemia virus Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - drug effects Genes, myc - drug effects Hemoglobins - metabolism Ionomycin - pharmacology Kinetics Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - metabolism Mice Molecular and cellular biology Molecular genetics Oncogenes - drug effects Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-myb RNA, Messenger - genetics RNA, Messenger - isolation & purification RNA, Messenger - metabolism Transcription. Transcription factor. Splicing. Rna processing Tumor Cells, Cultured
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