Hydroxyl Radical Footprint Analysis of Human Immunodeficiency Virus Reverse Transcriptase-Template·Primer Complexes

Human immunodeficiency virus type 1 reverse transcriptase protects sugar moieties of a model template·primer DNA in a region from positions +3 to -15 from hydroxyl radical attack. A protected region of equivalent size migrates in concert with the translocating enzyme, as shown by hydroxyl radical fo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-07, Vol.90 (13), p.5909-5913
Hauptverfasser:	Metzger, Willi, Hermann, Thomas, Schatz, Octavian, Stuart F. J. Le Grice, Heumann, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Deoxyribonucleic acid DNA Enzymes HIV HIV 1 Human immunodeficiency virus human immunodeficiency virus 1 Hydroxyl radicals Nucleic acids Polymerization RNA Sugars
Online-Zugang:	Volltext
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