Sensory and pulmonary irritation of aliphatic amines in mice: A structure-activity relationship study
The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15‐min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test...
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| Veröffentlicht in: | Journal of applied toxicology 1993-03, Vol.13 (2), p.129-135 |
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| creator | Gagnaire, F. Azim, S. Simon, P. Cossec, B. Bonnet, P. de Ceaurriz, J. |
| description | The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15‐min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test compound. Moreover, the sixteen amines were tested for pulmonary irritation by measuring the decrease in respiratory rate of (non‐anaesthetized) tracheally cannulated mice (RD50 TC). The RD50 and RD50 TC values and their ratios were related to n‐octanol/water partition coefficients (log P). The RD50 values associated with exposure to saturated amines ranged from 17 to 300 ppm. The RD50TC values for these saturated amines ranged from 35 to 489 ppm. The RD50 and RD50TC values of saturated amines were closely related to the n‐octanol/water partition coefficient, indicating that the more lipophilic amines are more irritant for the upper and lower respiratory tracts. The RD50TC/RD50 values were much less closely related to the n‐octanol/water partition coefficient.
Based on the results, tentative standards are suggested for the studied amines. |
| doi_str_mv | 10.1002/jat.2550130210 |
| format | Article |
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Based on the results, tentative standards are suggested for the studied amines.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550130210</identifier><identifier>PMID: 8486911</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Administration, Inhalation ; Air - analysis ; aliphatic amines ; Amines - toxicity ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical Phenomena ; Chemistry, Physical ; Irritants - toxicity ; Lipids - chemistry ; Lung Diseases - chemically induced ; Lung Diseases - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; nasal irritation ; Nasal Mucosa - drug effects ; Neurons, Afferent - drug effects ; pulmonry irritation ; Regression Analysis ; Structure-Activity Relationship ; Time Factors ; Toxicology ; Various organic compounds</subject><ispartof>Journal of applied toxicology, 1993-03, Vol.13 (2), p.129-135</ispartof><rights>Copyright © 1993 John Wiley & Sons, Ltd.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4690-de9d1afcf2db9d168044c7b87d4031eb4ab55937e2d7f63423b50cb4730d9abc3</citedby><cites>FETCH-LOGICAL-c4690-de9d1afcf2db9d168044c7b87d4031eb4ab55937e2d7f63423b50cb4730d9abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550130210$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550130210$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4761834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8486911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gagnaire, F.</creatorcontrib><creatorcontrib>Azim, S.</creatorcontrib><creatorcontrib>Simon, P.</creatorcontrib><creatorcontrib>Cossec, B.</creatorcontrib><creatorcontrib>Bonnet, P.</creatorcontrib><creatorcontrib>de Ceaurriz, J.</creatorcontrib><title>Sensory and pulmonary irritation of aliphatic amines in mice: A structure-activity relationship study</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15‐min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test compound. Moreover, the sixteen amines were tested for pulmonary irritation by measuring the decrease in respiratory rate of (non‐anaesthetized) tracheally cannulated mice (RD50 TC). The RD50 and RD50 TC values and their ratios were related to n‐octanol/water partition coefficients (log P). The RD50 values associated with exposure to saturated amines ranged from 17 to 300 ppm. The RD50TC values for these saturated amines ranged from 35 to 489 ppm. The RD50 and RD50TC values of saturated amines were closely related to the n‐octanol/water partition coefficient, indicating that the more lipophilic amines are more irritant for the upper and lower respiratory tracts. The RD50TC/RD50 values were much less closely related to the n‐octanol/water partition coefficient.
Based on the results, tentative standards are suggested for the studied amines.</description><subject>Administration, Inhalation</subject><subject>Air - analysis</subject><subject>aliphatic amines</subject><subject>Amines - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Irritants - toxicity</subject><subject>Lipids - chemistry</subject><subject>Lung Diseases - chemically induced</subject><subject>Lung Diseases - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>nasal irritation</subject><subject>Nasal Mucosa - drug effects</subject><subject>Neurons, Afferent - drug effects</subject><subject>pulmonry irritation</subject><subject>Regression Analysis</subject><subject>Structure-Activity Relationship</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlvFDEQhS1EFCaBKzckHxC3npSXttvcJiMIRGGRGJab5Xa7FYfesN2B-fc4mdEgTjlVld73ylY9hJ4TWBIAenZj0pKWJRAGlMAjtCCgVEGoYI_RAqiAgjP54wk6ifEGIGu0OkbHFa-EImSB3Bc3xDFssRkaPM1dPw4mTz4En0zy44DHFpvOT9d5stj0fnAR-wH33rrXeIVjCrNNc3CFscnf-rTFwXX31njtp6zPzfYpOmpNF92zfT1FX9--2azfFVefLt6vV1eF5UJB0TjVENPaljZ17kQFnFtZV7LhwIiruanLUjHpaCNbwThldQm25pJBo0xt2Sl6tds7hfHX7GLSvY_WdZ0Z3DhHTYTgipTlwyBnUEmlMrjcgTaMMQbX6in4Pp9IE9B3AegcgP4XQDa82G-e6941B3x_8ay_3OsmWtO1wQzWxwPGpSAV4xlTO-y379z2gUf15Wrz3xeKndfH5P4cvCb81EIyWervHy_0t_XmnH64VPoz-wuuv69U</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Gagnaire, F.</creator><creator>Azim, S.</creator><creator>Simon, P.</creator><creator>Cossec, B.</creator><creator>Bonnet, P.</creator><creator>de Ceaurriz, J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>199303</creationdate><title>Sensory and pulmonary irritation of aliphatic amines in mice: A structure-activity relationship study</title><author>Gagnaire, F. ; Azim, S. ; Simon, P. ; Cossec, B. ; Bonnet, P. ; de Ceaurriz, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4690-de9d1afcf2db9d168044c7b87d4031eb4ab55937e2d7f63423b50cb4730d9abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Inhalation</topic><topic>Air - analysis</topic><topic>aliphatic amines</topic><topic>Amines - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Irritants - toxicity</topic><topic>Lipids - chemistry</topic><topic>Lung Diseases - chemically induced</topic><topic>Lung Diseases - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>nasal irritation</topic><topic>Nasal Mucosa - drug effects</topic><topic>Neurons, Afferent - drug effects</topic><topic>pulmonry irritation</topic><topic>Regression Analysis</topic><topic>Structure-Activity Relationship</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gagnaire, F.</creatorcontrib><creatorcontrib>Azim, S.</creatorcontrib><creatorcontrib>Simon, P.</creatorcontrib><creatorcontrib>Cossec, B.</creatorcontrib><creatorcontrib>Bonnet, P.</creatorcontrib><creatorcontrib>de Ceaurriz, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gagnaire, F.</au><au>Azim, S.</au><au>Simon, P.</au><au>Cossec, B.</au><au>Bonnet, P.</au><au>de Ceaurriz, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensory and pulmonary irritation of aliphatic amines in mice: A structure-activity relationship study</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>13</volume><issue>2</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15‐min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD50) was calculated for each test compound. Moreover, the sixteen amines were tested for pulmonary irritation by measuring the decrease in respiratory rate of (non‐anaesthetized) tracheally cannulated mice (RD50 TC). The RD50 and RD50 TC values and their ratios were related to n‐octanol/water partition coefficients (log P). The RD50 values associated with exposure to saturated amines ranged from 17 to 300 ppm. The RD50TC values for these saturated amines ranged from 35 to 489 ppm. The RD50 and RD50TC values of saturated amines were closely related to the n‐octanol/water partition coefficient, indicating that the more lipophilic amines are more irritant for the upper and lower respiratory tracts. The RD50TC/RD50 values were much less closely related to the n‐octanol/water partition coefficient.
Based on the results, tentative standards are suggested for the studied amines.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8486911</pmid><doi>10.1002/jat.2550130210</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Inhalation Air - analysis aliphatic amines Amines - toxicity Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical Phenomena Chemistry, Physical Irritants - toxicity Lipids - chemistry Lung Diseases - chemically induced Lung Diseases - pathology Male Medical sciences Mice Mice, Inbred Strains nasal irritation Nasal Mucosa - drug effects Neurons, Afferent - drug effects pulmonry irritation Regression Analysis Structure-Activity Relationship Time Factors Toxicology Various organic compounds |
| title | Sensory and pulmonary irritation of aliphatic amines in mice: A structure-activity relationship study |
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