Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract

Abstract Acetyl-11-keto-β-boswellic acid (AKBA), a gum resin extract, possesses poor water-solubility that limits bioavailability and a high melting point making it difficult to successfully process into solid dispersions by fusion methods. The purpose of this study was to investigate solvent and th...

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Veröffentlicht in:	Drug development and industrial pharmacy 2015-03, Vol.41 (3), p.382-397
Hauptverfasser:	Bennett, Ryan C., Brough, Chris, Miller, Dave A., O'Donnell, Kevin P., Keen, Justin M., Hughey, Justin R., Williams, Robert O., McGinity, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous solid dispersions Animals bioavailability enhancement Chemistry, Pharmaceutical - methods Frankincense - chemical synthesis Frankincense - metabolism hot melt extrusion KinetiSol Dispersing Male Plant Gums - chemical synthesis Plant Gums - metabolism Rats Rats, Sprague-Dawley rotary evaporation Solubility supersaturation Triterpenes - chemical synthesis Triterpenes - metabolism Water - chemistry Water - metabolism X-Ray Diffraction
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