ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line

Interactions between ATP and adenosine on the formation of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and mobilization of intracellular calcium were investigated in the smooth muscle cell line DDT1 MF-2. Activation of adenosine A1 receptors with adenosine or cyclopentyladenosine (CPA) or of nucleot...

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Veröffentlicht in:	The Journal of biological chemistry 1992-08, Vol.267 (23), p.16081-16087
Hauptverfasser:	GERWINS, P, FREDHOLM, B. B
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - analogs & derivatives Adenosine - metabolism Adenosine - pharmacology Adenosine Deaminase - pharmacology Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals ATP Biological and medical sciences calcium Calcium - metabolism Cell Line cell lines Cell receptors Cell structures and functions Colforsin - pharmacology Cyclic AMP - metabolism Dose-Response Relationship, Drug formation Fundamental and applied biological sciences. Psychology hamsters inositol 1,4,5-trisphosphate Inositol 1,4,5-Trisphosphate - metabolism Kinetics Leiomyosarcoma metabolites Miscellaneous mobilization Molecular and cellular biology Muscle, Smooth Pertussis Toxin Purinergic Antagonists Receptors, Purinergic - drug effects Receptors, Purinergic - physiology smooth muscle Theophylline - analogs & derivatives Theophylline - pharmacology Type C Phospholipases - metabolism Virulence Factors, Bordetella - pharmacology
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