Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

Stimulation of glucose transport is the main physiological effect of insulin in target tissues. This effect is linked to translocation of the GLUT4 glucose transporter from an intracellular pool to the cell surface. To elucidate the molecular mechanisms involved in this effect, we developed a simple...

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Veröffentlicht in:	The Journal of biological chemistry 1993-07, Vol.268 (19), p.14523-14526
Hauptverfasser:	KANAI, F, NISHIOKA, Y, HAYASHI, H, KAMOHARA, S, TODAKA, M, EBINA, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipose Tissue - drug effects Adipose Tissue - metabolism Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Binding and carrier proteins Biological and medical sciences Biological Transport - drug effects Cell Membrane - metabolism CHO Cells Cricetinae Deoxyglucose - metabolism DNA Epitopes - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Genes, myc Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanylyl Imidodiphosphate - pharmacology Insulin - pharmacology Kinetics Mice Molecular Sequence Data Monosaccharide Transport Proteins - biosynthesis Mutagenesis, Insertional Protein Processing, Post-Translational - drug effects Proteins Sodium Fluoride - pharmacology Tetradecanoylphorbol Acetate - pharmacology Transfection
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