Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors

A series of benzothiadiazine derivatives were screened against the human immunodeficiency virus (HIV) and certain structure-activity relationships were defined for anti-HIV activity in this chemical class. The selected representative NSC 287474 was a highly potent inhibitor of HIV-induced cell killi...

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Veröffentlicht in:	Antiviral research 1994-09, Vol.25 (1), p.43-56
Hauptverfasser:	Buckheit, Robert W., Fliakas-Boltz, Valerie, Decker, W.Don, Roberson, Joseph L., Pyle, Cathi A., White, E.Lucile, Bowdon, Bonnie J., McMahon, James B., Boyd, Michael R., Bader, John P., Nickell, David G., Barth, Hubert, Antonucci, Tammy K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Base Sequence Benzothiadiazine Benzothiadiazines - pharmacology Biological and medical sciences Cell Line Cells, Cultured Combination therapy Drug Evaluation, Preclinical Drug Resistance, Microbial Drug Synergism HIV Reverse Transcriptase HIV-1 - drug effects HIV-1 - physiology HIV-2 - drug effects HIV-2 - physiology human immunodeficiency virus Humans Mechanism of action Medical sciences Molecular Sequence Data Nonnucleoside reverse transcriptase inhibitor Pharmacology. Drug treatments Reverse Transcriptase Inhibitors Structure-Activity Relationship Virus Replication - drug effects Zidovudine - pharmacology
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