Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells

Although serum bile acid concentrations are approximately 10 µM in healthy subjects, the crosstalk between the biliary system and vascular repair has never been investigated. In this study, tauroursodeoxycholic acid (TUDCA) induced dissociation of CD34+ hematopoietic stem cells (HSCs) from stromal c...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2015-03, Vol.33 (3), p.792-805
Hauptverfasser:	Cho, Jin Gu, Lee, Jun Hee, Hong, Shin Hee, Lee, Han Na, Kim, Chul Min, Kim, Seo Yoon, Yoon, Kang Jun, Oh, Bae Jun, Kim, Jae Hyeon, Jung, Seok Yoon, Asahara, Takayuki, Kwon, Sang‐Mo, Park, Sang Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adult Animals Blood Vessels - cytology Blood Vessels - drug effects Bone marrow Cell Differentiation - physiology Endothelial Cells - cytology Endothelial Cells - metabolism Endothelial colony forming cells Female Hematopoietic stem cell Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Neovascularization, Pathologic - pathology Nitric oxide Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Taurochenodeoxycholic Acid - pharmacology Tauroursodeoxycholic acid
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