Heterologous production of caffeic acid from tyrosine in Escherichia coli

•Escherichia coli was engineered for the production of caffeic acid.•Tyrosine ammonia lyase (TAL) converted 3mM of tyrosine to 2.62mM p-coumaric acid.•TAL and 4-coumarate 3-hydroxylase (C3H) converted tyrosine in 1mM caffeic acid.•This is the first study that shows caffeic acid production using TAL...

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Veröffentlicht in:	Enzyme and microbial technology 2015-04, Vol.71, p.36-44
Hauptverfasser:	Rodrigues, J.L., Araújo, R.G., Prather, K.L.J., Kluskens, L.D., Rodrigues, L.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria - enzymology Actinobacteria - genetics Ammonia-Lyases - genetics Ammonia-Lyases - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biosynthesis Biosynthetic Pathways Caffeic acid Caffeic Acids - metabolism Coumaric Acids - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism DNA, Bacterial - genetics E. coli Escherichia coli K12 - genetics Escherichia coli K12 - metabolism Genes, Bacterial Genetic Engineering Molecular Sequence Data p-Coumaric acid Propionates Recombinant Proteins - genetics Recombinant Proteins - metabolism Rhodopseudomonas - enzymology Rhodopseudomonas - genetics Rhodotorula - enzymology Rhodotorula - genetics Science & Technology Synthetic biology Tyrosine Tyrosine - metabolism
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