TMBIM protein family: ancestral regulators of cell death
The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This...
Gespeichert in:
| Veröffentlicht in: | Oncogene 2015-01, Vol.34 (3), p.269-280 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 280 |
|---|---|
| container_issue | 3 |
| container_start_page | 269 |
| container_title | Oncogene |
| container_volume | 34 |
| creator | Rojas-Rivera, D Hetz, C |
| description | The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This group of proteins is composed of at least six highly conserved members expressed in mammals, with homologs in insects, fish, plants, viruses and yeast. Different studies indicate that all TMBIM family members have inhibitory activities in different setting of apoptosis. Here, we overview and integrate possible mechanisms underlying the impact of the TMBIM protein family in the regulation of cell death, which include activities at diverse subcellular compartments, including death receptor regulation, modulation of endoplasmic reticulum (ER) calcium homeostasis, ER stress signaling, autophagy, reactive oxygen species production, among other effects. The possible intersection between the BCL-2 and TMBIM family in the control of cell death is also discussed, in addition to their implication in the progression of cancer. |
| doi_str_mv | 10.1038/onc.2014.6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1664209350</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A488535790</galeid><sourcerecordid>A488535790</sourcerecordid><originalsourceid>FETCH-LOGICAL-c651t-4fd94cdd5c3c53d41a7cc7d8892c7465a5eda2710720d9ac288965bccbb434733</originalsourceid><addsrcrecordid>eNqNkUtLAzEUhYMotlY3_gAZcCPK1Lwz406LL2hxU9chTTJ1ysykJjML_70prVIfiGQRyP3uybn3AHCM4BBBkl26Rg8xRHTId0AfUcFTxnK6C_owZzDNMcE9cBDCAkIocoj3QQ9TxhHDWR9k08nN4yRZetfaskkKVZfV21WiGm1D61WVeDvvKtU6HxJXJNpWVWKsal8OwV6hqmCPNvcAPN_dTkcP6fjp_nF0PU41Z6hNaWFyqo1hmmhGDEVKaC1MluVYC8qZYtYoLBAUGJpcaRwrnM20ns0ooYKQAThb60aLr100JesyrGyoxrouSMQ5xTAnDP4HhZRSQnBET7-hC9f5Jg4iMSGIExJl_6IQp4wJgfAWNVeVlWVTuLg4vfpaXtMsY4TFrUdq-AsVj7F1qV1jizK-f2k4Xzdo70LwtpBLX9bKv0kE5Sp3GXOXq9wlj_DJxmk3q635RD-CjsDFGgix1Myt3xrlp9w7hNmxkw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1645577124</pqid></control><display><type>article</type><title>TMBIM protein family: ancestral regulators of cell death</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Journals Online</source><creator>Rojas-Rivera, D ; Hetz, C</creator><creatorcontrib>Rojas-Rivera, D ; Hetz, C</creatorcontrib><description>The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This group of proteins is composed of at least six highly conserved members expressed in mammals, with homologs in insects, fish, plants, viruses and yeast. Different studies indicate that all TMBIM family members have inhibitory activities in different setting of apoptosis. Here, we overview and integrate possible mechanisms underlying the impact of the TMBIM protein family in the regulation of cell death, which include activities at diverse subcellular compartments, including death receptor regulation, modulation of endoplasmic reticulum (ER) calcium homeostasis, ER stress signaling, autophagy, reactive oxygen species production, among other effects. The possible intersection between the BCL-2 and TMBIM family in the control of cell death is also discussed, in addition to their implication in the progression of cancer.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2014.6</identifier><identifier>PMID: 24561528</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/612/1237 ; 631/67/395 ; 631/80/82/23 ; 692/699/67 ; Animals ; Apoptosis ; Apoptosis - genetics ; Apoptosis Regulatory Proteins - genetics ; Apoptosis Regulatory Proteins - metabolism ; Autophagy ; BAX protein ; Bcl-2 protein ; Calcium (reticular) ; Calcium homeostasis ; Calcium signalling ; Cancer ; Carcinogenesis ; Cell Biology ; Cell death ; Cellular signal transduction ; Endoplasmic reticulum ; Endoplasmic Reticulum Stress - genetics ; Genetic aspects ; Health aspects ; Homeostasis ; Human Genetics ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Membrane proteins ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mitochondria ; Models, Genetic ; Multigene Family ; Neoplasms - genetics ; Oncology ; Pathology ; Phagocytosis ; Protein expression ; Proteins ; Reactive oxygen species ; Regulation ; review ; Signal Transduction - genetics</subject><ispartof>Oncogene, 2015-01, Vol.34 (3), p.269-280</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 15, 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c651t-4fd94cdd5c3c53d41a7cc7d8892c7465a5eda2710720d9ac288965bccbb434733</citedby><cites>FETCH-LOGICAL-c651t-4fd94cdd5c3c53d41a7cc7d8892c7465a5eda2710720d9ac288965bccbb434733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/onc.2014.6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/onc.2014.6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24561528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rojas-Rivera, D</creatorcontrib><creatorcontrib>Hetz, C</creatorcontrib><title>TMBIM protein family: ancestral regulators of cell death</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This group of proteins is composed of at least six highly conserved members expressed in mammals, with homologs in insects, fish, plants, viruses and yeast. Different studies indicate that all TMBIM family members have inhibitory activities in different setting of apoptosis. Here, we overview and integrate possible mechanisms underlying the impact of the TMBIM protein family in the regulation of cell death, which include activities at diverse subcellular compartments, including death receptor regulation, modulation of endoplasmic reticulum (ER) calcium homeostasis, ER stress signaling, autophagy, reactive oxygen species production, among other effects. The possible intersection between the BCL-2 and TMBIM family in the control of cell death is also discussed, in addition to their implication in the progression of cancer.</description><subject>631/45/612/1237</subject><subject>631/67/395</subject><subject>631/80/82/23</subject><subject>692/699/67</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Autophagy</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>Calcium (reticular)</subject><subject>Calcium homeostasis</subject><subject>Calcium signalling</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Cellular signal transduction</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum Stress - genetics</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane proteins</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mitochondria</subject><subject>Models, Genetic</subject><subject>Multigene Family</subject><subject>Neoplasms - genetics</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Phagocytosis</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Regulation</subject><subject>review</subject><subject>Signal Transduction - genetics</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUtLAzEUhYMotlY3_gAZcCPK1Lwz406LL2hxU9chTTJ1ysykJjML_70prVIfiGQRyP3uybn3AHCM4BBBkl26Rg8xRHTId0AfUcFTxnK6C_owZzDNMcE9cBDCAkIocoj3QQ9TxhHDWR9k08nN4yRZetfaskkKVZfV21WiGm1D61WVeDvvKtU6HxJXJNpWVWKsal8OwV6hqmCPNvcAPN_dTkcP6fjp_nF0PU41Z6hNaWFyqo1hmmhGDEVKaC1MluVYC8qZYtYoLBAUGJpcaRwrnM20ns0ooYKQAThb60aLr100JesyrGyoxrouSMQ5xTAnDP4HhZRSQnBET7-hC9f5Jg4iMSGIExJl_6IQp4wJgfAWNVeVlWVTuLg4vfpaXtMsY4TFrUdq-AsVj7F1qV1jizK-f2k4Xzdo70LwtpBLX9bKv0kE5Sp3GXOXq9wlj_DJxmk3q635RD-CjsDFGgix1Myt3xrlp9w7hNmxkw</recordid><startdate>20150115</startdate><enddate>20150115</enddate><creator>Rojas-Rivera, D</creator><creator>Hetz, C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150115</creationdate><title>TMBIM protein family: ancestral regulators of cell death</title><author>Rojas-Rivera, D ; Hetz, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c651t-4fd94cdd5c3c53d41a7cc7d8892c7465a5eda2710720d9ac288965bccbb434733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/45/612/1237</topic><topic>631/67/395</topic><topic>631/80/82/23</topic><topic>692/699/67</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Apoptosis Regulatory Proteins - genetics</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Autophagy</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>Calcium (reticular)</topic><topic>Calcium homeostasis</topic><topic>Calcium signalling</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Cell Biology</topic><topic>Cell death</topic><topic>Cellular signal transduction</topic><topic>Endoplasmic reticulum</topic><topic>Endoplasmic Reticulum Stress - genetics</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membrane proteins</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mitochondria</topic><topic>Models, Genetic</topic><topic>Multigene Family</topic><topic>Neoplasms - genetics</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Phagocytosis</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Reactive oxygen species</topic><topic>Regulation</topic><topic>review</topic><topic>Signal Transduction - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rojas-Rivera, D</creatorcontrib><creatorcontrib>Hetz, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rojas-Rivera, D</au><au>Hetz, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TMBIM protein family: ancestral regulators of cell death</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2015-01-15</date><risdate>2015</risdate><volume>34</volume><issue>3</issue><spage>269</spage><epage>280</epage><pages>269-280</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The control of apoptosis in mammals has been historically associated with the activity of the BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death regulators have emerged, known as the Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) protein family. This group of proteins is composed of at least six highly conserved members expressed in mammals, with homologs in insects, fish, plants, viruses and yeast. Different studies indicate that all TMBIM family members have inhibitory activities in different setting of apoptosis. Here, we overview and integrate possible mechanisms underlying the impact of the TMBIM protein family in the regulation of cell death, which include activities at diverse subcellular compartments, including death receptor regulation, modulation of endoplasmic reticulum (ER) calcium homeostasis, ER stress signaling, autophagy, reactive oxygen species production, among other effects. The possible intersection between the BCL-2 and TMBIM family in the control of cell death is also discussed, in addition to their implication in the progression of cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24561528</pmid><doi>10.1038/onc.2014.6</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 2015-01, Vol.34 (3), p.269-280 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1664209350 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online |
| subjects | 631/45/612/1237 631/67/395 631/80/82/23 692/699/67 Animals Apoptosis Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Autophagy BAX protein Bcl-2 protein Calcium (reticular) Calcium homeostasis Calcium signalling Cancer Carcinogenesis Cell Biology Cell death Cellular signal transduction Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Genetic aspects Health aspects Homeostasis Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mitochondria Models, Genetic Multigene Family Neoplasms - genetics Oncology Pathology Phagocytosis Protein expression Proteins Reactive oxygen species Regulation review Signal Transduction - genetics |
| title | TMBIM protein family: ancestral regulators of cell death |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T16%3A24%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TMBIM%20protein%20family:%20ancestral%20regulators%20of%20cell%20death&rft.jtitle=Oncogene&rft.au=Rojas-Rivera,%20D&rft.date=2015-01-15&rft.volume=34&rft.issue=3&rft.spage=269&rft.epage=280&rft.pages=269-280&rft.issn=0950-9232&rft.eissn=1476-5594&rft.coden=ONCNES&rft_id=info:doi/10.1038/onc.2014.6&rft_dat=%3Cgale_proqu%3EA488535790%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1645577124&rft_id=info:pmid/24561528&rft_galeid=A488535790&rfr_iscdi=true |