The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells

Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), especially for the poor prognostic subgroup of NOTCH1 -mutated patients. Here, we report that the γ-secretase inhibitor PF-03084014 inhibits the constitutive Notch activation and induces...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2015-01, Vol.29 (1), p.96-106
Hauptverfasser:	López-Guerra, M, Xargay-Torrent, S, Rosich, L, Montraveta, A, Roldán, J, Matas-Céspedes, A, Villamor, N, Aymerich, M, López-Otín, C, Pérez-Galán, P, Roué, G, Campo, E, Colomer, D
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/21 13/31 13/89 13/95 38/39 38/61 631/67/1059/602 631/67/1059/99 631/67/1990/283/1895 82/29 Activation Aged Amyloid Precursor Protein Secretases - antagonists & inhibitors Angiogenesis Anticancer properties Apoptosis Cancer Research Cell migration Chemotaxis Chemotherapy Chronic lymphocytic leukemia Critical Care Medicine CXCL12 protein Development and progression Drug therapy Drug therapy, Combination Enzyme inhibitors Enzyme Inhibitors - pharmacology Female Fludarabine Gelatinase B Hematology Humans Inhibitors Intensive Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Male Medicine Medicine & Public Health Methods Middle Aged Mutation Neoplasm Invasiveness - prevention & control Neoplasm Metastasis - prevention & control Neovascularization, Pathologic - prevention & control Notch1 protein Oncology original-article Patient outcomes Rac2 protein Receptor, Notch1 - genetics Secretase Signaling Stroma Subgroups Tetrahydronaphthalenes - pharmacology Therapeutic applications Transcription Tumor Cells, Cultured Valine - analogs & derivatives Valine - pharmacology Vidarabine - analogs & derivatives Vidarabine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!