Immune responses to airborne fungi and non-invasive airway diseases
Inhalation of fungal particles is a ubiquitous way of exposure to microorganisms during human life; however, this exposure may promote or exacerbate respiratory diseases only in particular exposure conditions and human genetic background. Depending on the fungal species and form, fungal particles ca...
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Veröffentlicht in: | Seminars in immunopathology 2015-03, Vol.37 (2), p.83-96 |
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description | Inhalation of fungal particles is a ubiquitous way of exposure to microorganisms during human life; however, this exposure may promote or exacerbate respiratory diseases only in particular exposure conditions and human genetic background. Depending on the fungal species and form, fungal particles can induce symptoms in the lung by acting as irritants, aeroallergens or pathogens causing infection. Some thermophilic species can even act in all these three ways (e.g.
Aspergillus
,
Penicillium
), mesophilic species being only involved in allergic and/or non-allergic airway diseases (e.g.
Cladosporium
,
Alternaria
,
Fusarium
). The goal of the present review is to present the current knowledge on the interaction between airborne fungal particles and the host immune system, to illustrate the differences of immune sensing of different fungal species and to emphasise the importance of conducting research on non-conventional mesophilic fungal species. Indeed, the diversity of fungal species we inhale and the complexity of their composition have a direct impact on fungal particle recognition and immune system decision to tolerate or respond to those particles, eventually leading to collateral damages promoting airway pathologies. |
doi_str_mv | 10.1007/s00281-014-0471-3 |
format | Article |
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Aspergillus
,
Penicillium
), mesophilic species being only involved in allergic and/or non-allergic airway diseases (e.g.
Cladosporium
,
Alternaria
,
Fusarium
). The goal of the present review is to present the current knowledge on the interaction between airborne fungal particles and the host immune system, to illustrate the differences of immune sensing of different fungal species and to emphasise the importance of conducting research on non-conventional mesophilic fungal species. Indeed, the diversity of fungal species we inhale and the complexity of their composition have a direct impact on fungal particle recognition and immune system decision to tolerate or respond to those particles, eventually leading to collateral damages promoting airway pathologies.</description><identifier>ISSN: 1863-2297</identifier><identifier>EISSN: 1863-2300</identifier><identifier>DOI: 10.1007/s00281-014-0471-3</identifier><identifier>PMID: 25502371</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Allergens - immunology ; Alternaria ; Antigens, Fungal - immunology ; Aspergillus ; Asthma ; Biomedical and Life Sciences ; Biomedicine ; Chronic obstructive pulmonary disease ; Cladosporium ; Cytokines ; Fungi ; Fungi - immunology ; Fungi - metabolism ; Fusarium ; Genetic Predisposition to Disease ; Genetic Variation ; Host-Pathogen Interactions - genetics ; Host-Pathogen Interactions - immunology ; Humans ; Hypersensitivity - immunology ; Hypersensitivity - microbiology ; Immune system ; Immunology ; Internal Medicine ; Microorganisms ; Mycoses - genetics ; Mycoses - immunology ; Mycoses - transmission ; Pathogens ; Penicillium ; Respiratory diseases ; Respiratory Tract Infections - genetics ; Respiratory Tract Infections - immunology ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - transmission ; Review ; Risk Factors</subject><ispartof>Seminars in immunopathology, 2015-03, Vol.37 (2), p.83-96</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-89f7d0293ffa1d1137b2c8166fe992373c4342db83f51bf6fa6007d4e491a6eb3</citedby><cites>FETCH-LOGICAL-c481t-89f7d0293ffa1d1137b2c8166fe992373c4342db83f51bf6fa6007d4e491a6eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00281-014-0471-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00281-014-0471-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25502371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vacher, Gaëlle</creatorcontrib><creatorcontrib>Niculita-Hirzel, Hélène</creatorcontrib><creatorcontrib>Roger, Thierry</creatorcontrib><title>Immune responses to airborne fungi and non-invasive airway diseases</title><title>Seminars in immunopathology</title><addtitle>Semin Immunopathol</addtitle><addtitle>Semin Immunopathol</addtitle><description>Inhalation of fungal particles is a ubiquitous way of exposure to microorganisms during human life; however, this exposure may promote or exacerbate respiratory diseases only in particular exposure conditions and human genetic background. Depending on the fungal species and form, fungal particles can induce symptoms in the lung by acting as irritants, aeroallergens or pathogens causing infection. Some thermophilic species can even act in all these three ways (e.g.
Aspergillus
,
Penicillium
), mesophilic species being only involved in allergic and/or non-allergic airway diseases (e.g.
Cladosporium
,
Alternaria
,
Fusarium
). The goal of the present review is to present the current knowledge on the interaction between airborne fungal particles and the host immune system, to illustrate the differences of immune sensing of different fungal species and to emphasise the importance of conducting research on non-conventional mesophilic fungal species. Indeed, the diversity of fungal species we inhale and the complexity of their composition have a direct impact on fungal particle recognition and immune system decision to tolerate or respond to those particles, eventually leading to collateral damages promoting airway pathologies.</description><subject>Allergens - immunology</subject><subject>Alternaria</subject><subject>Antigens, Fungal - immunology</subject><subject>Aspergillus</subject><subject>Asthma</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cladosporium</subject><subject>Cytokines</subject><subject>Fungi</subject><subject>Fungi - immunology</subject><subject>Fungi - metabolism</subject><subject>Fusarium</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - microbiology</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Microorganisms</subject><subject>Mycoses - genetics</subject><subject>Mycoses - immunology</subject><subject>Mycoses - transmission</subject><subject>Pathogens</subject><subject>Penicillium</subject><subject>Respiratory diseases</subject><subject>Respiratory Tract Infections - genetics</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Respiratory Tract Infections - transmission</subject><subject>Review</subject><subject>Risk Factors</subject><issn>1863-2297</issn><issn>1863-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE9LAzEQxYMotlY_gBdZ8OIlmkmym-xRin8KBS96DtndpGzpJjXpVvrtTdlWRPCUIfN7b2YeQtdA7oEQ8RAJoRIwAY4JF4DZCRqDLBimjJDTY01LMUIXMS4JyQXLxTka0TwnlAkYo-ms63pnsmDi2rtoYrbxmW5D5UP6tb1btJl2Tea8w63b6thuzb7_pXdZ00ajk-QSnVm9iubq8E7Qx_PT-_QVz99eZtPHOa65hA2WpRUNoSWzVkMDwERFawlFYU1Zpm1YzRmnTSWZzaGyhdVFOrLhhpegC1OxCbobfNfBf_YmblTXxtqsVtoZ30eVrDglJSTrCbr9gy59H1zaLlE5l5IwJhMFA1UHH2MwVq1D2-mwU0DUPmE1JKxSwmqfsGJJc3Nw7qvOND-KY6QJoAMQU8stTPg1-l_Xb4PghLU</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Vacher, Gaëlle</creator><creator>Niculita-Hirzel, Hélène</creator><creator>Roger, Thierry</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>M7N</scope></search><sort><creationdate>20150301</creationdate><title>Immune responses to airborne fungi and non-invasive airway diseases</title><author>Vacher, Gaëlle ; Niculita-Hirzel, Hélène ; Roger, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-89f7d0293ffa1d1137b2c8166fe992373c4342db83f51bf6fa6007d4e491a6eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Allergens - immunology</topic><topic>Alternaria</topic><topic>Antigens, Fungal - immunology</topic><topic>Aspergillus</topic><topic>Asthma</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cladosporium</topic><topic>Cytokines</topic><topic>Fungi</topic><topic>Fungi - immunology</topic><topic>Fungi - metabolism</topic><topic>Fusarium</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - microbiology</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Microorganisms</topic><topic>Mycoses - genetics</topic><topic>Mycoses - immunology</topic><topic>Mycoses - transmission</topic><topic>Pathogens</topic><topic>Penicillium</topic><topic>Respiratory diseases</topic><topic>Respiratory Tract Infections - genetics</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Respiratory Tract Infections - transmission</topic><topic>Review</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vacher, Gaëlle</creatorcontrib><creatorcontrib>Niculita-Hirzel, Hélène</creatorcontrib><creatorcontrib>Roger, Thierry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Seminars in immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vacher, Gaëlle</au><au>Niculita-Hirzel, Hélène</au><au>Roger, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune responses to airborne fungi and non-invasive airway diseases</atitle><jtitle>Seminars in immunopathology</jtitle><stitle>Semin Immunopathol</stitle><addtitle>Semin Immunopathol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>37</volume><issue>2</issue><spage>83</spage><epage>96</epage><pages>83-96</pages><issn>1863-2297</issn><eissn>1863-2300</eissn><abstract>Inhalation of fungal particles is a ubiquitous way of exposure to microorganisms during human life; however, this exposure may promote or exacerbate respiratory diseases only in particular exposure conditions and human genetic background. Depending on the fungal species and form, fungal particles can induce symptoms in the lung by acting as irritants, aeroallergens or pathogens causing infection. Some thermophilic species can even act in all these three ways (e.g.
Aspergillus
,
Penicillium
), mesophilic species being only involved in allergic and/or non-allergic airway diseases (e.g.
Cladosporium
,
Alternaria
,
Fusarium
). The goal of the present review is to present the current knowledge on the interaction between airborne fungal particles and the host immune system, to illustrate the differences of immune sensing of different fungal species and to emphasise the importance of conducting research on non-conventional mesophilic fungal species. Indeed, the diversity of fungal species we inhale and the complexity of their composition have a direct impact on fungal particle recognition and immune system decision to tolerate or respond to those particles, eventually leading to collateral damages promoting airway pathologies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25502371</pmid><doi>10.1007/s00281-014-0471-3</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; SpringerNature Journals |
subjects | Allergens - immunology Alternaria Antigens, Fungal - immunology Aspergillus Asthma Biomedical and Life Sciences Biomedicine Chronic obstructive pulmonary disease Cladosporium Cytokines Fungi Fungi - immunology Fungi - metabolism Fusarium Genetic Predisposition to Disease Genetic Variation Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Humans Hypersensitivity - immunology Hypersensitivity - microbiology Immune system Immunology Internal Medicine Microorganisms Mycoses - genetics Mycoses - immunology Mycoses - transmission Pathogens Penicillium Respiratory diseases Respiratory Tract Infections - genetics Respiratory Tract Infections - immunology Respiratory Tract Infections - microbiology Respiratory Tract Infections - transmission Review Risk Factors |
title | Immune responses to airborne fungi and non-invasive airway diseases |
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