Evolutionary trajectories of hyperdiploid ALL in monozygotic twins

Identical twins have provided unique insights on timing or sequence of genetic events in acute lymphoblastic leukaemia (ALL). To date, this has mainly focused on ALL with MLL or ETV6-RUNX1 fusions, with hyperdiploid ALL remaining less well characterised. We examined three pairs of monozygotic twins,...

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Veröffentlicht in:	Leukemia 2015-01, Vol.29 (1), p.58-65
Hauptverfasser:	Bateman, C M, Alpar, D, Ford, A M, Colman, S M, Wren, D, Morgan, M, Kearney, L, Greaves, M
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 45/61 631/67/69 Acute lymphoblastic leukemia Acute lymphocytic leukemia Bone marrow Cancer Research Care and treatment CD19 antigen Chromosomes Copy number Copy number variations Critical Care Medicine Development and progression Diagnosis Diploidy DNA Primers Evolution, Molecular Exome Gene mutation Gene polymorphism Gene Rearrangement, T-Lymphocyte Gene sequencing Genes, Immunoglobulin Genetic aspects Genomes Health aspects Heavy chains Hematology Humans Identification and classification Immunoglobulins Intensive Internal Medicine Leukemia Low level Lymphocytes B Medical research Medicine Medicine & Public Health Mutation Nucleotides Oncology original-article Polymorphism Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Real-Time Polymerase Chain Reaction Remission (Medicine) Runx1 protein Single nucleotide polymorphisms Single-nucleotide polymorphism Twins Twins, Monozygotic
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