NAD-dependent ADP-ribosylation of the human antimicrobial and immune-modulatory peptide LL-37 by ADP-ribosyltransferase-1

LL-37 is a cationic peptide belonging to the cathelicidin family that has antimicrobial and immune-modulatory properties. Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vi...

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Veröffentlicht in:	Innate immunity (London, England) England), 2015-04, Vol.21 (3), p.314-321
Hauptverfasser:	Picchianti, Monica, Russo, Carla, Castagnini, Marta, Biagini, Massimiliano, Soldaini, Elisabetta, Balducci, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - metabolism ADP Ribose Transferases - metabolism Animals Antimicrobial Cationic Peptides - metabolism Arginine - metabolism Cell Line Cell Membrane - metabolism GPI-Linked Proteins - metabolism Humans Immunomodulation Mass Spectrometry NAD - metabolism
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