ZRF1 controls the retinoic acid pathway and regulates leukemogenic potential in acute myeloid leukemia

Acute myeloid leukemia (AML) is frequently linked to epigenetic abnormalities and deregulation of gene transcription, which lead to aberrant cell proliferation and accumulation of undifferentiated precursors. ZRF1, a recently characterized epigenetic factor involved in transcriptional regulation, is...

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Veröffentlicht in:	Oncogene 2014-11, Vol.33 (48), p.5501-5510
Hauptverfasser:	Demajo, S, Uribesalgo, I, Gutiérrez, A, Ballaré, C, Capdevila, S, Roth, M, Zuber, J, Martín-Caballero, J, Di Croce, L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/1897 631/80/86 692/420/755 Acids Acute myeloid leukemia Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Blotting, Western Cell Biology Cell differentiation Cell Differentiation - drug effects Cell Differentiation - genetics Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenetics Gene Expression Regulation, Neoplastic - physiology Gene regulation Genes Genomes Human Genetics Humans Immunoprecipitation Internal Medicine Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Medicine Medicine & Public Health Mice Mice, SCID Molecular Chaperones Oligonucleotide Array Sequence Analysis Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncology original-article Properties Retinoic acid RNA-Binding Proteins Rodents Signal Transduction - drug effects Signal Transduction - physiology Transcription factors Transcription, Genetic Transfection Tretinoin - metabolism Tretinoin - pharmacology Xenograft Model Antitumor Assays Xenografts
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