Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Activation of myofibroblast rich stroma is a rate-limiting step essential for cancer progression. The responsible factors are not fully understood, but TGFβ1 is probably critical. A proportion of TGFβ1 is associated with extracellular nano-vesicles termed exosomes, secreted by carcinoma cells, and t...

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Veröffentlicht in:	Oncogene 2015-01, Vol.34 (3), p.290-302
Hauptverfasser:	Webber, J P, Spary, L K, Sanders, A J, Chowdhury, R, Jiang, W G, Steadman, R, Wymant, J, Jones, A T, Kynaston, H, Mason, M D, Tabi, Z, Clayton, A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/67/589/466 631/80/86 692/420/755 Angiogenesis Animals Apoptosis Cancer Carcinogenesis Cell Biology Cell Differentiation Cell Line, Tumor Cells, Cultured Cellular biology Exosomes Exosomes - metabolism Fibroblasts Gene Knockdown Techniques Genetic aspects Health aspects Heparan sulfate Heparitin Sulfate - metabolism Heparitin Sulfate - pharmacology Human Genetics Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Immunoblotting Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Male Medicine Medicine & Public Health Mice, Nude Myofibroblasts - drug effects Myofibroblasts - metabolism Oncology Organelles original-article Phenotypes Prostate Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein expression rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism rab27 GTP-Binding Proteins Secretome Smad protein Stromal cells Stromal Cells - drug effects Stromal Cells - metabolism Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Transforming growth factors Transplantation, Heterologous Tumors
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