5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes

Poly(adenosine 5′-diphosphate ribose) polymerase (PARP) is a nuclear enzyme activated by DNA strand breaks and plays an important role in the tissue injury associated with ischemia and reperfusion. The aim of the present study was to investigate the protective effect of 5-aminoisoquinolinone (5-AIQ)...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-04, Vol.268 (1), p.90-98
Hauptverfasser:	Park, Eun-Seok, Kang, Jun Chul, Kang, Do-Hyun, Jang, Yong Chang, Yi, Kyu Yang, Chung, Hun-Jong, Park, Jong Seok, Kim, Bokyung, Feng, Zhong-Ping, Shin, Hwa-Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	5-AIQ Akt/glycogen synthase kinase-3β Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Cell Line Cell Survival - drug effects Cell Survival - physiology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - pharmacology In Situ Nick-End Labeling Isoquinolines - pharmacology Medical sciences Myocardial apoptosis Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidative Stress - drug effects PARP inhibitor Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction - drug effects Toxicology
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