TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4 super(+) T cell fate and interact with Runx3 to silence Cd4 in CD8 super(+) T cells

The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4 super(+)CD8 super(+) double-positive (DP) stage are unknown. By specific ablation of these factors in DP thymocytes, we demonstrated that deficiency in TCF-1 and LEF-1 diminished the...

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Veröffentlicht in:	Nature immunology 2014-07, Vol.15 (7), p.646-656
Hauptverfasser:	Steinke, Farrah C, Yu, Shuyang, Zhou, Xinyuan, He, Bing, Yang, Wenjing, Zhou, Bo, Kawamoto, Hiroshi, Zhu, Jun, Tan, Kai, Xue, Hai-Hui
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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